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Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation

Four stress-sensing kinases phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) to activate the integrated stress response (ISR). In animals, the ISR is antagonised by selective eIF2α phosphatases comprising a catalytic protein phosphatase 1 (PP1) subunit in complex...

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Detalles Bibliográficos
Autores principales:	Chambers, Joseph E, Dalton, Lucy E, Clarke, Hanna J, Malzer, Elke, Dominicus, Caia S, Patel, Vruti, Moorhead, Greg, Ron, David, Marciniak, Stefan J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394351/ https://www.ncbi.nlm.nih.gov/pubmed/25774599 http://dx.doi.org/10.7554/eLife.04872

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