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Treatment of obstructive sleep apnea with oral appliances

BACKGROUND: The purpose of this study was to evaluate the effectiveness of mandibular advancement devices (MADs) for treatment of obstructive sleep apnea syndrome (OSAS) compared with the results obtained with a placebo device in accordance with the following indicators: apnea hypopnea index (AHI) p...

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Autores principales: Teixeira, Andressa Otranto de Britto, Abi-Ramia, Luciana Baptista Pereira, Almeida, Marco Antonio de Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394371/
https://www.ncbi.nlm.nih.gov/pubmed/24326088
http://dx.doi.org/10.1186/2196-1042-14-10
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author Teixeira, Andressa Otranto de Britto
Abi-Ramia, Luciana Baptista Pereira
Almeida, Marco Antonio de Oliveira
author_facet Teixeira, Andressa Otranto de Britto
Abi-Ramia, Luciana Baptista Pereira
Almeida, Marco Antonio de Oliveira
author_sort Teixeira, Andressa Otranto de Britto
collection PubMed
description BACKGROUND: The purpose of this study was to evaluate the effectiveness of mandibular advancement devices (MADs) for treatment of obstructive sleep apnea syndrome (OSAS) compared with the results obtained with a placebo device in accordance with the following indicators: apnea hypopnea index (AHI) per hour of sleep, apnea index (AI) per hour of sleep, mean oxyhemoglobin saturation, sleep efficiency, and percentage of rapid eye movement (REM) sleep. METHODS: This is a controlled, prospective longitudinal study with a follow-up time of 10.5 months. Nineteen patients (8 females and 11 males) with mean age 48.6 years (SD 9.6) were selected for the study. The sample was randomized in terms of device use, and the evaluation design was double blind. A total of 57 polysomnography tests were studied (at baseline, after the use of a MAD, and after the use of placebo). The following variables were assessed: AHI, AI, mean oxyhemoglobin saturation, percentage of REM sleep, and sleep efficiency. Wilcoxon and Mann–Whitney tests were used for evaluating data (p < 0.05). RESULTS: Reductions from 16.3 to 11.7 in AHI and from 5.7 to 3.8 in AI were observed after MAD use. During the use of placebo, AHI increased from 16.3 to 19.6, and AI from 5.7 to 7.5. The other indexes showed no statistically significant differences. CONCLUSIONS: Treatment with oral appliances, i.e., MADs, can be an effective alternative for mild and medium-to-moderate OSAS, but requires strict monitoring due to differences in individual response to this therapy.
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spelling pubmed-43943712015-04-14 Treatment of obstructive sleep apnea with oral appliances Teixeira, Andressa Otranto de Britto Abi-Ramia, Luciana Baptista Pereira Almeida, Marco Antonio de Oliveira Prog Orthod Research BACKGROUND: The purpose of this study was to evaluate the effectiveness of mandibular advancement devices (MADs) for treatment of obstructive sleep apnea syndrome (OSAS) compared with the results obtained with a placebo device in accordance with the following indicators: apnea hypopnea index (AHI) per hour of sleep, apnea index (AI) per hour of sleep, mean oxyhemoglobin saturation, sleep efficiency, and percentage of rapid eye movement (REM) sleep. METHODS: This is a controlled, prospective longitudinal study with a follow-up time of 10.5 months. Nineteen patients (8 females and 11 males) with mean age 48.6 years (SD 9.6) were selected for the study. The sample was randomized in terms of device use, and the evaluation design was double blind. A total of 57 polysomnography tests were studied (at baseline, after the use of a MAD, and after the use of placebo). The following variables were assessed: AHI, AI, mean oxyhemoglobin saturation, percentage of REM sleep, and sleep efficiency. Wilcoxon and Mann–Whitney tests were used for evaluating data (p < 0.05). RESULTS: Reductions from 16.3 to 11.7 in AHI and from 5.7 to 3.8 in AI were observed after MAD use. During the use of placebo, AHI increased from 16.3 to 19.6, and AI from 5.7 to 7.5. The other indexes showed no statistically significant differences. CONCLUSIONS: Treatment with oral appliances, i.e., MADs, can be an effective alternative for mild and medium-to-moderate OSAS, but requires strict monitoring due to differences in individual response to this therapy. Springer-Verlag 2013-05-23 /pmc/articles/PMC4394371/ /pubmed/24326088 http://dx.doi.org/10.1186/2196-1042-14-10 Text en © Teixeira et al.; licensee Springer. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Teixeira, Andressa Otranto de Britto
Abi-Ramia, Luciana Baptista Pereira
Almeida, Marco Antonio de Oliveira
Treatment of obstructive sleep apnea with oral appliances
title Treatment of obstructive sleep apnea with oral appliances
title_full Treatment of obstructive sleep apnea with oral appliances
title_fullStr Treatment of obstructive sleep apnea with oral appliances
title_full_unstemmed Treatment of obstructive sleep apnea with oral appliances
title_short Treatment of obstructive sleep apnea with oral appliances
title_sort treatment of obstructive sleep apnea with oral appliances
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394371/
https://www.ncbi.nlm.nih.gov/pubmed/24326088
http://dx.doi.org/10.1186/2196-1042-14-10
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