Hologram QSAR Models of a Series of 6-Arylquinazolin-4-Amine Inhibitors of a New Alzheimer’s Disease Target: Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase-1A Enzyme

Dual specificity tyrosine-phosphorylation-regulated kinase-1A (DYRK1A) is an enzyme directly involved in Alzheimer’s disease, since its increased expression leads to β-amyloidosis, Tau protein aggregation, and subsequent formation of neurofibrillary tangles. Hologram quantitative structure-activity...

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Detalles Bibliográficos
Autores principales: Leal, Felipe Dias, da Silva Lima, Camilo Henrique, de Alencastro, Ricardo Bicca, Castro, Helena Carla, Rodrigues, Carlos Rangel, Albuquerque, Magaly Girão
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394473/
https://www.ncbi.nlm.nih.gov/pubmed/25756379
http://dx.doi.org/10.3390/ijms16035235

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