Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women

The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile wo...

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Detalles Bibliográficos
Autores principales: Rizzo, Roberta, Lo Monte, Giuseppe, Bortolotti, Daria, Graziano, Angela, Gentili, Valentina, Di Luca, Dario, Marci, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394489/
https://www.ncbi.nlm.nih.gov/pubmed/25764161
http://dx.doi.org/10.3390/ijms16035510
Descripción
Sumario:The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile women in comparison with women with secondary infertility. Lower CD56(+)KIR2DL4(+) (e)NK cell percentages were detected in primary infertile women compared with secondary infertile women. This is the first study demonstrating that primary and secondary unexplained infertilities are characterized by different basal sHLA-G levels and CD56(+)KIR2DL4(+) (e)NK cell percentages.

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