Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women

The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile wo...

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Detalles Bibliográficos
Autores principales: Rizzo, Roberta, Lo Monte, Giuseppe, Bortolotti, Daria, Graziano, Angela, Gentili, Valentina, Di Luca, Dario, Marci, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394489/
https://www.ncbi.nlm.nih.gov/pubmed/25764161
http://dx.doi.org/10.3390/ijms16035510
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author Rizzo, Roberta
Lo Monte, Giuseppe
Bortolotti, Daria
Graziano, Angela
Gentili, Valentina
Di Luca, Dario
Marci, Roberto
author_facet Rizzo, Roberta
Lo Monte, Giuseppe
Bortolotti, Daria
Graziano, Angela
Gentili, Valentina
Di Luca, Dario
Marci, Roberto
author_sort Rizzo, Roberta
collection PubMed
description The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile women in comparison with women with secondary infertility. Lower CD56(+)KIR2DL4(+) (e)NK cell percentages were detected in primary infertile women compared with secondary infertile women. This is the first study demonstrating that primary and secondary unexplained infertilities are characterized by different basal sHLA-G levels and CD56(+)KIR2DL4(+) (e)NK cell percentages.
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spelling pubmed-43944892015-05-21 Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women Rizzo, Roberta Lo Monte, Giuseppe Bortolotti, Daria Graziano, Angela Gentili, Valentina Di Luca, Dario Marci, Roberto Int J Mol Sci Short Communication The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile women in comparison with women with secondary infertility. Lower CD56(+)KIR2DL4(+) (e)NK cell percentages were detected in primary infertile women compared with secondary infertile women. This is the first study demonstrating that primary and secondary unexplained infertilities are characterized by different basal sHLA-G levels and CD56(+)KIR2DL4(+) (e)NK cell percentages. MDPI 2015-03-10 /pmc/articles/PMC4394489/ /pubmed/25764161 http://dx.doi.org/10.3390/ijms16035510 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short Communication
Rizzo, Roberta
Lo Monte, Giuseppe
Bortolotti, Daria
Graziano, Angela
Gentili, Valentina
Di Luca, Dario
Marci, Roberto
Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women
title Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women
title_full Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women
title_fullStr Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women
title_full_unstemmed Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women
title_short Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women
title_sort impact of soluble hla-g levels and endometrial nk cells in uterine flushing samples from primary and secondary unexplained infertile women
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394489/
https://www.ncbi.nlm.nih.gov/pubmed/25764161
http://dx.doi.org/10.3390/ijms16035510
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