Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi

Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi. The structu...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Shi-Yie, Wang, Shang-Kwei, Hsieh, Mu-Keng, Duh, Chang-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394524/
https://www.ncbi.nlm.nih.gov/pubmed/25789502
http://dx.doi.org/10.3390/ijms16036140
_version_ 1782366304175390720
author Cheng, Shi-Yie
Wang, Shang-Kwei
Hsieh, Mu-Keng
Duh, Chang-Yih
author_facet Cheng, Shi-Yie
Wang, Shang-Kwei
Hsieh, Mu-Keng
Duh, Chang-Yih
author_sort Cheng, Shi-Yie
collection PubMed
description Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi. The structures of 1–5 were established on the basis of comprehensive NMR and HR-ESI-MS analyses and by comparison with reported data in the literature. Compounds 4 and 5 showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC(50) values of 2.0 and 3.0 μM, respectively. Compound 2 exhibited slight antiviral activity against HCMV (human cytomegalovirus) with IC(50) values of 25.0 μg/mL.
format Online
Article
Text
id pubmed-4394524
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-43945242015-05-21 Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi Cheng, Shi-Yie Wang, Shang-Kwei Hsieh, Mu-Keng Duh, Chang-Yih Int J Mol Sci Article Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi. The structures of 1–5 were established on the basis of comprehensive NMR and HR-ESI-MS analyses and by comparison with reported data in the literature. Compounds 4 and 5 showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC(50) values of 2.0 and 3.0 μM, respectively. Compound 2 exhibited slight antiviral activity against HCMV (human cytomegalovirus) with IC(50) values of 25.0 μg/mL. MDPI 2015-03-17 /pmc/articles/PMC4394524/ /pubmed/25789502 http://dx.doi.org/10.3390/ijms16036140 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Shi-Yie
Wang, Shang-Kwei
Hsieh, Mu-Keng
Duh, Chang-Yih
Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi
title Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi
title_full Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi
title_fullStr Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi
title_full_unstemmed Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi
title_short Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi
title_sort polyoxygenated cembrane diterpenoids from the soft coral sarcophyton ehrenbergi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394524/
https://www.ncbi.nlm.nih.gov/pubmed/25789502
http://dx.doi.org/10.3390/ijms16036140
work_keys_str_mv AT chengshiyie polyoxygenatedcembranediterpenoidsfromthesoftcoralsarcophytonehrenbergi
AT wangshangkwei polyoxygenatedcembranediterpenoidsfromthesoftcoralsarcophytonehrenbergi
AT hsiehmukeng polyoxygenatedcembranediterpenoidsfromthesoftcoralsarcophytonehrenbergi
AT duhchangyih polyoxygenatedcembranediterpenoidsfromthesoftcoralsarcophytonehrenbergi

Ejemplares similares