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Physiologically Based Pharmacokinetic Modeling of Fluorescently Labeled Block Copolymer Nanoparticles for Controlled Drug Delivery in Leukemia Therapy

A physiologically based pharmacokinetic (PBPK) model was developed that describes the concentration and biodistribution of fluorescently labeled nanoparticles in mice used for the controlled delivery of dexamethasone in acute lymphoblastic leukemia (ALL) therapy. The simulated data showed initial sp...

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Detalles Bibliográficos
Autores principales:	Gilkey, MJ, Krishnan, V, Scheetz, L, Jia, X, Rajasekaran, AK, Dhurjati, PS
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394613/ https://www.ncbi.nlm.nih.gov/pubmed/26225236 http://dx.doi.org/10.1002/psp4.13

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