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Model-Based Design of a Decision Tree for Treating HER2+ Cancers Based on Genetic and Protein Biomarkers

Human cancers are incredibly diverse with regard to molecular aberrations, dependence on oncogenic signaling pathways, and responses to pharmacological intervention. We wished to assess how cellular dependence on the canonical PI3K vs. MAPK pathways within HER2+ cancers affects responses to combinat...

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Detalles Bibliográficos
Autores principales:	Kirouac, DC, Lahdenranta, J, Du, J, Yarar, D, Onsum, MD, Nielsen, UB, McDonagh, CF
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394616/ https://www.ncbi.nlm.nih.gov/pubmed/26225238 http://dx.doi.org/10.1002/psp4.19

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