Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment

Systems pharmacology modeling and pharmacokinetic-pharmacodynamic (PK/PD) analysis of drug-induced effects on cardiovascular (CV) function plays a crucial role in understanding the safety risk of new drugs. The aim of this review is to outline the current modeling and simulation (M&S) approaches...

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Detalles Bibliográficos
Autores principales: Collins, TA, Bergenholm, L, Abdulla, T, Yates, JWT, Evans, N, Chappell, MJ, Mettetal, JT
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394617/
https://www.ncbi.nlm.nih.gov/pubmed/26225237
http://dx.doi.org/10.1002/psp4.18
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author Collins, TA
Bergenholm, L
Abdulla, T
Yates, JWT
Evans, N
Chappell, MJ
Mettetal, JT
author_facet Collins, TA
Bergenholm, L
Abdulla, T
Yates, JWT
Evans, N
Chappell, MJ
Mettetal, JT
author_sort Collins, TA
collection PubMed
description Systems pharmacology modeling and pharmacokinetic-pharmacodynamic (PK/PD) analysis of drug-induced effects on cardiovascular (CV) function plays a crucial role in understanding the safety risk of new drugs. The aim of this review is to outline the current modeling and simulation (M&S) approaches to describe and translate drug-induced CV effects, with an emphasis on how this impacts drug safety assessment. Current limitations are highlighted and recommendations are made for future effort in this vital area of drug research.
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spelling pubmed-43946172015-04-20 Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment Collins, TA Bergenholm, L Abdulla, T Yates, JWT Evans, N Chappell, MJ Mettetal, JT CPT Pharmacometrics Syst Pharmacol Review Systems pharmacology modeling and pharmacokinetic-pharmacodynamic (PK/PD) analysis of drug-induced effects on cardiovascular (CV) function plays a crucial role in understanding the safety risk of new drugs. The aim of this review is to outline the current modeling and simulation (M&S) approaches to describe and translate drug-induced CV effects, with an emphasis on how this impacts drug safety assessment. Current limitations are highlighted and recommendations are made for future effort in this vital area of drug research. BlackWell Publishing Ltd 2015-03 2015-03-11 /pmc/articles/PMC4394617/ /pubmed/26225237 http://dx.doi.org/10.1002/psp4.18 Text en © 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Collins, TA
Bergenholm, L
Abdulla, T
Yates, JWT
Evans, N
Chappell, MJ
Mettetal, JT
Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment
title Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment
title_full Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment
title_fullStr Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment
title_full_unstemmed Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment
title_short Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment
title_sort modeling and simulation approaches for cardiovascular function and their role in safety assessment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394617/
https://www.ncbi.nlm.nih.gov/pubmed/26225237
http://dx.doi.org/10.1002/psp4.18
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