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Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment

Systems pharmacology modeling and pharmacokinetic-pharmacodynamic (PK/PD) analysis of drug-induced effects on cardiovascular (CV) function plays a crucial role in understanding the safety risk of new drugs. The aim of this review is to outline the current modeling and simulation (M&S) approaches...

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Detalles Bibliográficos
Autores principales:	Collins, TA, Bergenholm, L, Abdulla, T, Yates, JWT, Evans, N, Chappell, MJ, Mettetal, JT
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394617/ https://www.ncbi.nlm.nih.gov/pubmed/26225237 http://dx.doi.org/10.1002/psp4.18

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