Immune-Mediated Necrotizing Myopathy, Associated With Antibodies to Signal Recognition Particle, Together With Lupus Nephritis: Case Presentation and Management

A male patient with limb weakness, myalgia and edema was subsequently found to have an immune-mediated necrotizing myopathy (IMNM) on biopsy. Targeted myopathic antibody analysis revealed antibodies to signal recognition particle (SRP). Anti-SRP-associated necrotizing myopathy was diagnosed. This ca...

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Detalles Bibliográficos
Autores principales: O’Grady, John, Harty, Len, Mayer, Nick, Critcher, Val, Ryan, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394925/
https://www.ncbi.nlm.nih.gov/pubmed/25883715
http://dx.doi.org/10.14740/jocmr2133w
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author O’Grady, John
Harty, Len
Mayer, Nick
Critcher, Val
Ryan, John
author_facet O’Grady, John
Harty, Len
Mayer, Nick
Critcher, Val
Ryan, John
author_sort O’Grady, John
collection PubMed
description A male patient with limb weakness, myalgia and edema was subsequently found to have an immune-mediated necrotizing myopathy (IMNM) on biopsy. Targeted myopathic antibody analysis revealed antibodies to signal recognition particle (SRP). Anti-SRP-associated necrotizing myopathy was diagnosed. This case was complicated by the concurrent development of class III lupus nephritis. We discuss an interesting case progression and development as well as the management of these difficult to treat conditions.
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spelling pubmed-43949252015-04-16 Immune-Mediated Necrotizing Myopathy, Associated With Antibodies to Signal Recognition Particle, Together With Lupus Nephritis: Case Presentation and Management O’Grady, John Harty, Len Mayer, Nick Critcher, Val Ryan, John J Clin Med Res Case Report A male patient with limb weakness, myalgia and edema was subsequently found to have an immune-mediated necrotizing myopathy (IMNM) on biopsy. Targeted myopathic antibody analysis revealed antibodies to signal recognition particle (SRP). Anti-SRP-associated necrotizing myopathy was diagnosed. This case was complicated by the concurrent development of class III lupus nephritis. We discuss an interesting case progression and development as well as the management of these difficult to treat conditions. Elmer Press 2015-06 2015-04-08 /pmc/articles/PMC4394925/ /pubmed/25883715 http://dx.doi.org/10.14740/jocmr2133w Text en Copyright 2015, O’Grady et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
O’Grady, John
Harty, Len
Mayer, Nick
Critcher, Val
Ryan, John
Immune-Mediated Necrotizing Myopathy, Associated With Antibodies to Signal Recognition Particle, Together With Lupus Nephritis: Case Presentation and Management
title Immune-Mediated Necrotizing Myopathy, Associated With Antibodies to Signal Recognition Particle, Together With Lupus Nephritis: Case Presentation and Management
title_full Immune-Mediated Necrotizing Myopathy, Associated With Antibodies to Signal Recognition Particle, Together With Lupus Nephritis: Case Presentation and Management
title_fullStr Immune-Mediated Necrotizing Myopathy, Associated With Antibodies to Signal Recognition Particle, Together With Lupus Nephritis: Case Presentation and Management
title_full_unstemmed Immune-Mediated Necrotizing Myopathy, Associated With Antibodies to Signal Recognition Particle, Together With Lupus Nephritis: Case Presentation and Management
title_short Immune-Mediated Necrotizing Myopathy, Associated With Antibodies to Signal Recognition Particle, Together With Lupus Nephritis: Case Presentation and Management
title_sort immune-mediated necrotizing myopathy, associated with antibodies to signal recognition particle, together with lupus nephritis: case presentation and management
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394925/
https://www.ncbi.nlm.nih.gov/pubmed/25883715
http://dx.doi.org/10.14740/jocmr2133w
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