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CNS Genes Implicated in Relapse
Drug abuse is a condition that impacts not only the individual drug user, but society as a whole. Although prevention of initial drug use is the most effective way to prevent addiction, avoiding relapse is a crucial component of drug addiction recovery. Recent studies suggest that there is a set of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395042/ https://www.ncbi.nlm.nih.gov/pubmed/25922574 |
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author | Kuntz-Melcavage, Kara L Freeman, Willard M Vrana, Kent E |
author_facet | Kuntz-Melcavage, Kara L Freeman, Willard M Vrana, Kent E |
author_sort | Kuntz-Melcavage, Kara L |
collection | PubMed |
description | Drug abuse is a condition that impacts not only the individual drug user, but society as a whole. Although prevention of initial drug use is the most effective way to prevent addiction, avoiding relapse is a crucial component of drug addiction recovery. Recent studies suggest that there is a set of genes whose expression is robustly and stably altered following drug use and ensuing abstinence. Such stable changes in gene expression correlate with ultrastructural changes in brain as well as alterations in behavior. As persistent molecular changes, these genes may provide targets for the development of therapeutics. Developing a list of well-characterized candidate genes and examining the effect of manipulating these genes will contribute to the ultimate goal of developing effective treatments to prevent relapse to drug use. |
format | Online Article Text |
id | pubmed-4395042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-43950422015-04-28 CNS Genes Implicated in Relapse Kuntz-Melcavage, Kara L Freeman, Willard M Vrana, Kent E Subst Abuse Review Drug abuse is a condition that impacts not only the individual drug user, but society as a whole. Although prevention of initial drug use is the most effective way to prevent addiction, avoiding relapse is a crucial component of drug addiction recovery. Recent studies suggest that there is a set of genes whose expression is robustly and stably altered following drug use and ensuing abstinence. Such stable changes in gene expression correlate with ultrastructural changes in brain as well as alterations in behavior. As persistent molecular changes, these genes may provide targets for the development of therapeutics. Developing a list of well-characterized candidate genes and examining the effect of manipulating these genes will contribute to the ultimate goal of developing effective treatments to prevent relapse to drug use. Libertas Academica 2008-09-25 /pmc/articles/PMC4395042/ /pubmed/25922574 Text en Copyright in this article, its metadata, and any supplementary data is held by its author or authors. It is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0/. |
spellingShingle | Review Kuntz-Melcavage, Kara L Freeman, Willard M Vrana, Kent E CNS Genes Implicated in Relapse |
title | CNS Genes Implicated in Relapse |
title_full | CNS Genes Implicated in Relapse |
title_fullStr | CNS Genes Implicated in Relapse |
title_full_unstemmed | CNS Genes Implicated in Relapse |
title_short | CNS Genes Implicated in Relapse |
title_sort | cns genes implicated in relapse |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395042/ https://www.ncbi.nlm.nih.gov/pubmed/25922574 |
work_keys_str_mv | AT kuntzmelcavagekaral cnsgenesimplicatedinrelapse AT freemanwillardm cnsgenesimplicatedinrelapse AT vranakente cnsgenesimplicatedinrelapse |