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Volatility of Mutator Phenotypes at Single Cell Resolution

Mutator phenotypes accelerate the evolutionary process of neoplastic transformation. Historically, the measurement of mutation rates has relied on scoring the occurrence of rare mutations in target genes in large populations of cells. Averaging mutation rates over large cell populations assumes that...

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Detalles Bibliográficos
Autores principales:	Kennedy, Scott R., Schultz, Eric M., Chappell, Thomas M., Kohrn, Brendan, Knowels, Gary M., Herr, Alan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395103/ https://www.ncbi.nlm.nih.gov/pubmed/25868109 http://dx.doi.org/10.1371/journal.pgen.1005151

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