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Phosphorylation at the Homotypic Interface Regulates Nucleoprotein Oligomerization and Assembly of the Influenza Virus Replication Machinery

Negative-sense RNA viruses assemble large ribonucleoprotein (RNP) complexes that direct replication and transcription of the viral genome. Influenza virus RNPs contain the polymerase, genomic RNA and multiple copies of nucleoprotein (NP). During RNP assembly, monomeric NP oligomerizes along the leng...

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Detalles Bibliográficos
Autores principales: Mondal, Arindam, Potts, Gregory K., Dawson, Anthony R., Coon, Joshua J., Mehle, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395114/
https://www.ncbi.nlm.nih.gov/pubmed/25867750
http://dx.doi.org/10.1371/journal.ppat.1004826