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Hepatitis C Virus RNA Replication Depends on Specific Cis- and Trans-Acting Activities of Viral Nonstructural Proteins

Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood. Here, we evaluate this concept for hepatitis C virus (HCV), an important cause of c...

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Detalles Bibliográficos
Autores principales:	Kazakov, Teymur, Yang, Feng, Ramanathan, Harish N., Kohlway, Andrew, Diamond, Michael S., Lindenbach, Brett D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395149/ https://www.ncbi.nlm.nih.gov/pubmed/25875808 http://dx.doi.org/10.1371/journal.ppat.1004817

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