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Dysfunctional Noise Cancelling of the Rostral Anterior Cingulate Cortex in Tinnitus Patients
BACKGROUND: Peripheral auditory deafferentation and central compensation have been regarded as the main culprits of tinnitus generation. However, patient-to-patient discrepancy in the range of the percentage of daytime in which tinnitus is perceived (tinnitus awareness percentage, 0 – 100%), is not...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395158/ https://www.ncbi.nlm.nih.gov/pubmed/25875099 http://dx.doi.org/10.1371/journal.pone.0123538 |
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author | Song, Jae Jin Vanneste, Sven De Ridder, Dirk |
author_facet | Song, Jae Jin Vanneste, Sven De Ridder, Dirk |
author_sort | Song, Jae Jin |
collection | PubMed |
description | BACKGROUND: Peripheral auditory deafferentation and central compensation have been regarded as the main culprits of tinnitus generation. However, patient-to-patient discrepancy in the range of the percentage of daytime in which tinnitus is perceived (tinnitus awareness percentage, 0 – 100%), is not fully explicable only by peripheral deafferentation, considering that the deafferentation is a stable persisting phenomenon but tinnitus is intermittently perceived in most patients. Consequently, the involvement of a dysfunctional noise cancellation mechanism has recently been suggested with regard to the individual differences in reported tinnitus awareness. By correlating the tinnitus awareness percentage with resting-state source-localized electroencephalography findings, we may be able to retrieve the cortical area that is negatively correlated with tinnitus awareness percentage, and then the area may be regarded as the core of the noise cancelling system that is defective in patients with tinnitus. METHODS AND FINDINGS: Using resting-state cortical oscillation, we investigated 80 tinnitus patients by correlating the tinnitus awareness percentage with their source-localized cortical oscillatory activity and functional connectivity. The activity of bilateral rostral anterior cingulate cortices (ACCs), left dorsal- and pregenual ACCs for the delta band, bilateral rostral/pregenual/subgenual ACCs for the theta band, and left rostral/pregenual ACC for the beta 1 band displayed significantly negative correlations with tinnitus awareness percentage. Also, the connectivity between the left primary auditory cortex (A1) and the rostral ACC, as well as between the left A1 and the subgenual ACC for the beta 1 band, were negatively correlated with tinnitus awareness percentage. CONCLUSIONS: These results may designate the role of the rostral ACC as the core of the descending noise cancellation system, and thus dysfunction of the rostral ACC may result in perception of tinnitus. The present study also opens a possibility of tinnitus modulation by neuromodulatory approaches targeting the rostral ACC. |
format | Online Article Text |
id | pubmed-4395158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43951582015-04-21 Dysfunctional Noise Cancelling of the Rostral Anterior Cingulate Cortex in Tinnitus Patients Song, Jae Jin Vanneste, Sven De Ridder, Dirk PLoS One Research Article BACKGROUND: Peripheral auditory deafferentation and central compensation have been regarded as the main culprits of tinnitus generation. However, patient-to-patient discrepancy in the range of the percentage of daytime in which tinnitus is perceived (tinnitus awareness percentage, 0 – 100%), is not fully explicable only by peripheral deafferentation, considering that the deafferentation is a stable persisting phenomenon but tinnitus is intermittently perceived in most patients. Consequently, the involvement of a dysfunctional noise cancellation mechanism has recently been suggested with regard to the individual differences in reported tinnitus awareness. By correlating the tinnitus awareness percentage with resting-state source-localized electroencephalography findings, we may be able to retrieve the cortical area that is negatively correlated with tinnitus awareness percentage, and then the area may be regarded as the core of the noise cancelling system that is defective in patients with tinnitus. METHODS AND FINDINGS: Using resting-state cortical oscillation, we investigated 80 tinnitus patients by correlating the tinnitus awareness percentage with their source-localized cortical oscillatory activity and functional connectivity. The activity of bilateral rostral anterior cingulate cortices (ACCs), left dorsal- and pregenual ACCs for the delta band, bilateral rostral/pregenual/subgenual ACCs for the theta band, and left rostral/pregenual ACC for the beta 1 band displayed significantly negative correlations with tinnitus awareness percentage. Also, the connectivity between the left primary auditory cortex (A1) and the rostral ACC, as well as between the left A1 and the subgenual ACC for the beta 1 band, were negatively correlated with tinnitus awareness percentage. CONCLUSIONS: These results may designate the role of the rostral ACC as the core of the descending noise cancellation system, and thus dysfunction of the rostral ACC may result in perception of tinnitus. The present study also opens a possibility of tinnitus modulation by neuromodulatory approaches targeting the rostral ACC. Public Library of Science 2015-04-13 /pmc/articles/PMC4395158/ /pubmed/25875099 http://dx.doi.org/10.1371/journal.pone.0123538 Text en © 2015 Song et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Song, Jae Jin Vanneste, Sven De Ridder, Dirk Dysfunctional Noise Cancelling of the Rostral Anterior Cingulate Cortex in Tinnitus Patients |
title | Dysfunctional Noise Cancelling of the Rostral Anterior Cingulate Cortex in Tinnitus Patients |
title_full | Dysfunctional Noise Cancelling of the Rostral Anterior Cingulate Cortex in Tinnitus Patients |
title_fullStr | Dysfunctional Noise Cancelling of the Rostral Anterior Cingulate Cortex in Tinnitus Patients |
title_full_unstemmed | Dysfunctional Noise Cancelling of the Rostral Anterior Cingulate Cortex in Tinnitus Patients |
title_short | Dysfunctional Noise Cancelling of the Rostral Anterior Cingulate Cortex in Tinnitus Patients |
title_sort | dysfunctional noise cancelling of the rostral anterior cingulate cortex in tinnitus patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395158/ https://www.ncbi.nlm.nih.gov/pubmed/25875099 http://dx.doi.org/10.1371/journal.pone.0123538 |
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