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Evaluation of Serum & Salivary IgA in Patients with Type 1 Diabetes

BACKGROUND: Diabetes mellitus is a common immune mediated disorder. The aim of the present study is to evaluate the level of serum and salivary IgA levels in patients with Type 1 diabetes. MATERIAL AND METHOD: In this case control study, serum and salivary IgA levels of patients with diabetes type 1...

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Autores principales: Ahmadiafshar, Akefeh, Mohsenifard, Mahmood Reza, Mazloomzadeh, Saeideh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395210/
https://www.ncbi.nlm.nih.gov/pubmed/25875365
http://dx.doi.org/10.1371/journal.pone.0122757
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author Ahmadiafshar, Akefeh
Mohsenifard, Mahmood Reza
Mazloomzadeh, Saeideh
author_facet Ahmadiafshar, Akefeh
Mohsenifard, Mahmood Reza
Mazloomzadeh, Saeideh
author_sort Ahmadiafshar, Akefeh
collection PubMed
description BACKGROUND: Diabetes mellitus is a common immune mediated disorder. The aim of the present study is to evaluate the level of serum and salivary IgA levels in patients with Type 1 diabetes. MATERIAL AND METHOD: In this case control study, serum and salivary IgA levels of patients with diabetes type 1 and similar non diabetes subjects were measured. Age, gender, duration of diabetes and the last HbA1c level of diabetic patients were also studied. Data was analyzed by SPSS software. RESULTS: Two hundred and fifty subjects (126 diabetics and 124 non diabetics) were enrolled in the study. The mean value of serum IgA in patients with Type 1 Diabetes and controls was 1.77± 1.55 g/lit and 2.39± 1.52 g/lit, respectively. The mean salivary IgA level in diabetics and controls was 276 ± 162.5 40 μg/ml and 129 ± 112.2 40 μg/ml, respectively. Selective IgA deficiency was detected in two (1.6%) and three(2.4%)cases of diabetic and control group; respectively (p=0.68). We found low salivary IgA level in 44.4% diabetic and 33.9% control (p=0.08). There was no significant correlation between serum and salivary IgA level. There was also significant association between serum IgA levels with age. Salivary IgA was significantly correlated with HbA1c level. But considering gender, duration of diabetes we didn’t find any association. CONCLUSION: We didn't find any significant difference in serum and salivary IgA level among diabetic and non diabetics and also, no association between serum and salivary IgA levels.
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spelling pubmed-43952102015-04-21 Evaluation of Serum & Salivary IgA in Patients with Type 1 Diabetes Ahmadiafshar, Akefeh Mohsenifard, Mahmood Reza Mazloomzadeh, Saeideh PLoS One Research Article BACKGROUND: Diabetes mellitus is a common immune mediated disorder. The aim of the present study is to evaluate the level of serum and salivary IgA levels in patients with Type 1 diabetes. MATERIAL AND METHOD: In this case control study, serum and salivary IgA levels of patients with diabetes type 1 and similar non diabetes subjects were measured. Age, gender, duration of diabetes and the last HbA1c level of diabetic patients were also studied. Data was analyzed by SPSS software. RESULTS: Two hundred and fifty subjects (126 diabetics and 124 non diabetics) were enrolled in the study. The mean value of serum IgA in patients with Type 1 Diabetes and controls was 1.77± 1.55 g/lit and 2.39± 1.52 g/lit, respectively. The mean salivary IgA level in diabetics and controls was 276 ± 162.5 40 μg/ml and 129 ± 112.2 40 μg/ml, respectively. Selective IgA deficiency was detected in two (1.6%) and three(2.4%)cases of diabetic and control group; respectively (p=0.68). We found low salivary IgA level in 44.4% diabetic and 33.9% control (p=0.08). There was no significant correlation between serum and salivary IgA level. There was also significant association between serum IgA levels with age. Salivary IgA was significantly correlated with HbA1c level. But considering gender, duration of diabetes we didn’t find any association. CONCLUSION: We didn't find any significant difference in serum and salivary IgA level among diabetic and non diabetics and also, no association between serum and salivary IgA levels. Public Library of Science 2015-04-13 /pmc/articles/PMC4395210/ /pubmed/25875365 http://dx.doi.org/10.1371/journal.pone.0122757 Text en © 2015 Ahmadiafshar et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ahmadiafshar, Akefeh
Mohsenifard, Mahmood Reza
Mazloomzadeh, Saeideh
Evaluation of Serum & Salivary IgA in Patients with Type 1 Diabetes
title Evaluation of Serum & Salivary IgA in Patients with Type 1 Diabetes
title_full Evaluation of Serum & Salivary IgA in Patients with Type 1 Diabetes
title_fullStr Evaluation of Serum & Salivary IgA in Patients with Type 1 Diabetes
title_full_unstemmed Evaluation of Serum & Salivary IgA in Patients with Type 1 Diabetes
title_short Evaluation of Serum & Salivary IgA in Patients with Type 1 Diabetes
title_sort evaluation of serum & salivary iga in patients with type 1 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395210/
https://www.ncbi.nlm.nih.gov/pubmed/25875365
http://dx.doi.org/10.1371/journal.pone.0122757
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