Molecular Dynamics Simulation Reveals Insights into the Mechanism of Unfolding by the A130T/V Mutations within the MID1 Zinc-Binding Bbox1 Domain

The zinc-binding Bbox1 domain in protein MID1, a member of the TRIM family of proteins, facilitates the ubiquitination of the catalytic subunit of protein phosphatase 2A and alpha4, a protein regulator of PP2A. The natural mutation of residue A130 to a valine or threonine disrupts substrate recognit...

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Detalles Bibliográficos
Autores principales: Zhao, Yunjie, Zeng, Chen, Massiah, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395243/
https://www.ncbi.nlm.nih.gov/pubmed/25874572
http://dx.doi.org/10.1371/journal.pone.0124377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395243/
https://www.ncbi.nlm.nih.gov/pubmed/25874572
http://dx.doi.org/10.1371/journal.pone.0124377

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