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Nutritional Energy Stimulates NAD(+) Production to Promote Tankyrase-Mediated PARsylation in Insulinoma Cells

The poly-ADP-ribosylation (PARsylation) activity of tankyrase (TNKS) regulates diverse physiological processes including energy metabolism and wnt/β-catenin signaling. This TNKS activity uses NAD(+) as a co-substrate to post-translationally modify various acceptor proteins including TNKS itself. PAR...

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Detalles Bibliográficos
Autores principales:	Zhong, Linlin, Yeh, Tsung-Yin J., Hao, Jun, Pourtabatabaei, Nasim, Mahata, Sushil K., Shao, Jianhua, Chessler, Steven D., Chi, Nai-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395342/ https://www.ncbi.nlm.nih.gov/pubmed/25876076 http://dx.doi.org/10.1371/journal.pone.0122948

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