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Prognostic Value of Umbilical and Cerebral Doppler in Fetal Growth Restriction: Comparison of Dichorionic Twins and Singletons

OBJECTIVE: To compare the prognostic value of fetal Doppler in dichorionic twins and singletons by measuring the interval between diagnosis of an abnormal Doppler flow and birth in fetuses who are small for gestational age (SGA). DESIGN: Comparative retrospective study using a prospectively collecte...

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Autores principales: Vanlieferinghen, Sarah, Anselem, Olivia, Le Ray, Camille, Shen, Yao, Marcellin, Louis, Goffinet, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395410/
https://www.ncbi.nlm.nih.gov/pubmed/25875366
http://dx.doi.org/10.1371/journal.pone.0123067
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author Vanlieferinghen, Sarah
Anselem, Olivia
Le Ray, Camille
Shen, Yao
Marcellin, Louis
Goffinet, François
author_facet Vanlieferinghen, Sarah
Anselem, Olivia
Le Ray, Camille
Shen, Yao
Marcellin, Louis
Goffinet, François
author_sort Vanlieferinghen, Sarah
collection PubMed
description OBJECTIVE: To compare the prognostic value of fetal Doppler in dichorionic twins and singletons by measuring the interval between diagnosis of an abnormal Doppler flow and birth in fetuses who are small for gestational age (SGA). DESIGN: Comparative retrospective study using a prospectively collected database. SETTING: A level 3 maternity unit in France. POPULATION: Fetuses from singleton and dichorionic pregnancies who are SGA (vascular or unexplained), defined by an abdominal circumference (AC) measurement below the 10(th) percentile and confirmed by a birth weight below the 10(th) percentile. METHODS: Fisher's exact and Chi-2 tests were used to compare frequencies, and the Mann-Whitney-Wilcoxon test was used to compare medians in non-Gaussian distributions. MAIN OUTCOME MEASURES: Both neonatal outcomes and intervals between the first Doppler abnormality and birth were compared in the groups of dichorionic twins and singletons. RESULTS: Obstetric and neonatal outcome were similar in the 104 SGA dichorionic twins and 170 SGA singletons. Abnormalities of umbilical artery Doppler, regardless of type, appeared at the same frequency in both groups (52.9%) but were identified earlier in twins (25 versus 28 weeks, p = 0.02). Among fetuses with abnormal Doppler flow, the interval between the finding and birth was significantly longer in the twins than the singletons (44 vs 15 days, p<0.01). CONCLUSIONS: The prognostic value of an abnormal Doppler finding for the course of a pregnancy may be different in dichorionic twins and singletons. The management of women carrying SGA twins and the information provided to them should take these results into account.
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spelling pubmed-43954102015-04-21 Prognostic Value of Umbilical and Cerebral Doppler in Fetal Growth Restriction: Comparison of Dichorionic Twins and Singletons Vanlieferinghen, Sarah Anselem, Olivia Le Ray, Camille Shen, Yao Marcellin, Louis Goffinet, François PLoS One Research Article OBJECTIVE: To compare the prognostic value of fetal Doppler in dichorionic twins and singletons by measuring the interval between diagnosis of an abnormal Doppler flow and birth in fetuses who are small for gestational age (SGA). DESIGN: Comparative retrospective study using a prospectively collected database. SETTING: A level 3 maternity unit in France. POPULATION: Fetuses from singleton and dichorionic pregnancies who are SGA (vascular or unexplained), defined by an abdominal circumference (AC) measurement below the 10(th) percentile and confirmed by a birth weight below the 10(th) percentile. METHODS: Fisher's exact and Chi-2 tests were used to compare frequencies, and the Mann-Whitney-Wilcoxon test was used to compare medians in non-Gaussian distributions. MAIN OUTCOME MEASURES: Both neonatal outcomes and intervals between the first Doppler abnormality and birth were compared in the groups of dichorionic twins and singletons. RESULTS: Obstetric and neonatal outcome were similar in the 104 SGA dichorionic twins and 170 SGA singletons. Abnormalities of umbilical artery Doppler, regardless of type, appeared at the same frequency in both groups (52.9%) but were identified earlier in twins (25 versus 28 weeks, p = 0.02). Among fetuses with abnormal Doppler flow, the interval between the finding and birth was significantly longer in the twins than the singletons (44 vs 15 days, p<0.01). CONCLUSIONS: The prognostic value of an abnormal Doppler finding for the course of a pregnancy may be different in dichorionic twins and singletons. The management of women carrying SGA twins and the information provided to them should take these results into account. Public Library of Science 2015-04-13 /pmc/articles/PMC4395410/ /pubmed/25875366 http://dx.doi.org/10.1371/journal.pone.0123067 Text en © 2015 Vanlieferinghen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Vanlieferinghen, Sarah
Anselem, Olivia
Le Ray, Camille
Shen, Yao
Marcellin, Louis
Goffinet, François
Prognostic Value of Umbilical and Cerebral Doppler in Fetal Growth Restriction: Comparison of Dichorionic Twins and Singletons
title Prognostic Value of Umbilical and Cerebral Doppler in Fetal Growth Restriction: Comparison of Dichorionic Twins and Singletons
title_full Prognostic Value of Umbilical and Cerebral Doppler in Fetal Growth Restriction: Comparison of Dichorionic Twins and Singletons
title_fullStr Prognostic Value of Umbilical and Cerebral Doppler in Fetal Growth Restriction: Comparison of Dichorionic Twins and Singletons
title_full_unstemmed Prognostic Value of Umbilical and Cerebral Doppler in Fetal Growth Restriction: Comparison of Dichorionic Twins and Singletons
title_short Prognostic Value of Umbilical and Cerebral Doppler in Fetal Growth Restriction: Comparison of Dichorionic Twins and Singletons
title_sort prognostic value of umbilical and cerebral doppler in fetal growth restriction: comparison of dichorionic twins and singletons
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395410/
https://www.ncbi.nlm.nih.gov/pubmed/25875366
http://dx.doi.org/10.1371/journal.pone.0123067
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