Cargando…

Single- and Repeat-dose Oral Toxicity Studies of Lithospermum erythrorhizon Extract in Dogs

Lithospermum erythrorhizon has long been used in traditional Asian medicine for the treatment of diseases, including skin cancer. The oral toxicity of a hexane extract of Lithospermum erythrorhizon root (LEH) was investigated in Beagle dogs by using single escalating doses, two-week dose range-findi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nam, Chunja, Hwang, Jae-Sik, Kim, Myoung-Jun, Choi, Young Whan, Han, Kyoung-Goo, Kang, Jong-Koo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society Of Toxicology 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395658/ https://www.ncbi.nlm.nih.gov/pubmed/25874036 http://dx.doi.org/10.5487/TR.2015.31.1.077

Ejemplares similares

Acute and 28-Day Subacute Toxicity Studies of Hexane Extracts of the Roots of Lithospermum erythrorhizon in Sprague-Dawley Rats
por: Han, Chung-Tack, et al.
Publicado: (2015)

Protective Effects of Lithospermum erythrorhizon Against Cerulein-Induced Acute Pancreatitis
por: Choi, Sun Bok, et al.
Publicado: (2015)

Evidence and Potential Mechanism of Action of Lithospermum erythrorhizon and Its Active Components for Psoriasis
por: Wang, Jiao, et al.
Publicado: (2022)

Network Pharmacology Revealed the Mechanisms of Action of Lithospermum erythrorhizon Sieb on Atopic Dermatitis
por: Wang, Tianyi, et al.
Publicado: (2023)

Exploring the evolutionary process of alkannin/shikonin O-acyltransferases by a reliable Lithospermum erythrorhizon genome
por: Tang, Chengyi
Publicado: (2021)

Involvement of LeMDR, an ATP-binding cassette protein gene, in shikonin transport and biosynthesis in Lithospermum erythrorhizon
por: Zhu, Yu, et al.
Publicado: (2017)

Apple latent spherical virus (ALSV)-induced gene silencing in a medicinal plant, Lithospermum erythrorhizon
por: Izuishi, Yuki, et al.
Publicado: (2020)

Genome-Wide Comparison and Functional Characterization of HMGR Gene Family Associated with Shikonin Biosynthesis in Lithospermum erythrorhizon
por: Wang, Xuan, et al.
Publicado: (2023)

Hybrid de novo genome assembly of red gromwell (Lithospermum erythrorhizon) reveals evolutionary insight into shikonin biosynthesis
por: Auber, Robert P., et al.
Publicado: (2020)

Biosynthesis and Cytotoxic Properties of Ag, Au, and Bimetallic Nanoparticles Synthesized Using Lithospermum erythrorhizon Callus Culture Extract
por: Shkryl, Yury, et al.
Publicado: (2021)

Revealing Potential Bioactive Compounds and Mechanisms of Lithospermum erythrorhizon against COVID-19 via Network Pharmacology Study
por: Oh, Ki-Kwang, et al.
Publicado: (2022)

Inventory of ATP-binding cassette proteins in Lithospermum erythrorhizon as a model plant producing divergent secondary metabolites
por: Li, Hao, et al.
Publicado: (2022)

Transgenic studies reveal the positive role of LeEIL-1 in regulating shikonin biosynthesis in Lithospermum erythrorhizon hairy roots
por: Fang, Rongjun, et al.
Publicado: (2016)

Antiallergic Effects of N,N-dicoumaroylspermidine Isolated from Lithospermum erythrorhizon on Mast Cells and Ovalbumin-Induced Allergic Rhinitis
por: Le, Tam Thi, et al.
Publicado: (2022)

Reproductive and Developmental Toxicity Screening Test of Ethyl Hydrogen Adipate in Rats
por: Nam, Chunja, et al.
Publicado: (2016)

Characterization of Shikonin Derivative Secretion in Lithospermum erythrorhizon Hairy Roots as a Model of Lipid-Soluble Metabolite Secretion from Plants
por: Tatsumi, Kanade, et al.
Publicado: (2016)

Chemical Profiles and Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract in High Fat Diet Fed Mice
por: Choi, Doo Jin, et al.
Publicado: (2022)

Determination of Five Chemical Markers in DF Formula, the Herbal Composition of Ephedra intermedia, Rheum palmatum, and Lithospermum erythrorhizon, Using High-performance Liquid Chromatography-ultraviolet Detection
por: Jeong, Birang, et al.
Publicado: (2018)

Prunus mume and Lithospermum erythrorhizon Extracts Synergistically Prevent Visceral Adiposity by Improving Energy Metabolism through Potentiating Hypothalamic Leptin and Insulin Signalling in Ovariectomized Rats
por: Ko, Byoung-Seob, et al.
Publicado: (2013)

Protective Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract against Hepatic Steatosis in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mice
por: Choi, Doo Jin, et al.
Publicado: (2020)

Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice
por: Oh, Jin-Su, et al.
Publicado: (2021)

Genome-Wide Identification of LeBAHDs in Lithospermum erythrorhizon and In Vivo Transgenic Studies Confirm the Critical Roles of LeBAHD1/LeSAT1 in the Conversion of Shikonin to Acetylshikonin
por: Wang, Xuan, et al.
Publicado: (2022)

Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB
por: Prasad, Rajapaksha Gedara, et al.
Publicado: (2015)

Single and Repeated Oral Dose Toxicity and Genotoxicity of the Leaves of Butterbur
por: Park, Sangsu, et al.
Publicado: (2021)

Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs
por: Kim, Myoung-Seok, et al.
Publicado: (2012)

Repeated-dose 90-day oral toxicity study of GST in Sprague-Dawley rats
por: Kim, Sang Ho, et al.
Publicado: (2022)

Root-associated bacteria modulate the specialised metabolome of Lithospermum officinale L.
por: Varela Alonso, Alicia, et al.
Publicado: (2022)

Subchronic Oral Dose Toxicity of Freeze-dried Powder of Allomyrina dichotoma Larvae
por: Noh, Jung-Ho, et al.
Publicado: (2015)

Dynamics of alkannin/shikonin biosynthesis in response to jasmonate and salicylic acid in Lithospermum officinale
por: Ahmad, Muhammad, et al.
Publicado: (2022)

Single- and repeated-dose toxicities of aloe fermentation products in rats
por: Cho, Ju-Hyun, et al.
Publicado: (2011)

Acute and 4-Week Repeated-Dose Oral Toxicity Studies of Cirsium setidens in Rats
por: Lee, Jong Seok, et al.
Publicado: (2014)

De novo Sequencing and Comparative Transcriptomics of Floral Development of the Distylous Species Lithospermum multiflorum
por: Cohen, James I.
Publicado: (2016)

Dissection for Floral Micromorphology and Plastid Genome of Valuable Medicinal Borages Arnebia and Lithospermum (Boraginaceae)
por: Park, Inkyu, et al.
Publicado: (2020)

Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs
por: Yang, Hyuck-Joo, et al.
Publicado: (2018)

Repeated dose oral toxicity of Trivanga Bhasma in Swiss albino mice
por: Jamadagni, Pallavi S., et al.
Publicado: (2013)

4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
por: Yu, Wook-Joon, et al.
Publicado: (2013)

Evaluation of Genotoxicity and 28-day Oral Dose Toxicity on Freeze-dried Powder of Tenebrio molitor Larvae (Yellow Mealworm)
por: Han, So-Ri, et al.
Publicado: (2014)

A 13-Week Repeated Oral Dose Toxicity Study of ChondroT in Sprague-Dawley Rats
por: Jeong, Jiwon, et al.
Publicado: (2019)

The Effect of Lithospermum officinale, Silver Sulfadiazine and Alpha Ointments in Healing of Burn Wound Injuries in Rat
por: Mohtasham Amiri, Zahra, et al.
Publicado: (2017)

Evaluation of 2-week repeated oral dose toxicity of 100 nm zinc oxide nanoparticles in rats
por: Ko, Je-Won, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6sius99intk8a36g092320qngu