Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients

Epstein-Barr virus (EBV) has been used as a paradigm for studying host–virus interactions, not only because of its importance as a human oncogenic virus associated with several malignancies including nasopharyngeal carcinoma (NPC) but also owing to its sophisticated strategies to subvert the host an...

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Detalles Bibliográficos
Autores principales: Shen, Yong, Zhang, Suzhan, Sun, Ren, Wu, Tingting, Qian, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395660/
https://www.ncbi.nlm.nih.gov/pubmed/26038769
http://dx.doi.org/10.1038/emi.2015.20
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author Shen, Yong
Zhang, Suzhan
Sun, Ren
Wu, Tingting
Qian, Jing
author_facet Shen, Yong
Zhang, Suzhan
Sun, Ren
Wu, Tingting
Qian, Jing
author_sort Shen, Yong
collection PubMed
description Epstein-Barr virus (EBV) has been used as a paradigm for studying host–virus interactions, not only because of its importance as a human oncogenic virus associated with several malignancies including nasopharyngeal carcinoma (NPC) but also owing to its sophisticated strategies to subvert the host antiviral responses. An understanding of the interplay between EBV and NPC is critical for the development of EBV-targeted immunotherapy. Here, we summarize the current knowledge regarding the host immune responses and EBV immune evasion mechanisms in the context of NPC.
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spelling pubmed-43956602015-04-13 Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients Shen, Yong Zhang, Suzhan Sun, Ren Wu, Tingting Qian, Jing Emerg Microbes Infect Review Epstein-Barr virus (EBV) has been used as a paradigm for studying host–virus interactions, not only because of its importance as a human oncogenic virus associated with several malignancies including nasopharyngeal carcinoma (NPC) but also owing to its sophisticated strategies to subvert the host antiviral responses. An understanding of the interplay between EBV and NPC is critical for the development of EBV-targeted immunotherapy. Here, we summarize the current knowledge regarding the host immune responses and EBV immune evasion mechanisms in the context of NPC. Nature Publishing Group 2015-03 2015-03-25 /pmc/articles/PMC4395660/ /pubmed/26038769 http://dx.doi.org/10.1038/emi.2015.20 Text en Copyright © 2015 Shanghai Shangyixun Cultural Communication Co., Ltd http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Shen, Yong
Zhang, Suzhan
Sun, Ren
Wu, Tingting
Qian, Jing
Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients
title Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients
title_full Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients
title_fullStr Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients
title_full_unstemmed Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients
title_short Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients
title_sort understanding the interplay between host immunity and epstein-barr virus in npc patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395660/
https://www.ncbi.nlm.nih.gov/pubmed/26038769
http://dx.doi.org/10.1038/emi.2015.20
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