Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation

Tumor heterogeneity is of growing importance in the treatment of cancers. Mutational hot spots are prime locations for determining number and proportions of low variant allele frequency (VAF) tumor subclones by next generation sequencing. Low VAF detection is complicated by poor mapping efficiency i...

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Detalles Bibliográficos
Autores principales: Spence, Janice M, Spence, John P, Abumoussa, Andrew, Burack, W Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395979/
https://www.ncbi.nlm.nih.gov/pubmed/25874000
http://dx.doi.org/10.1186/s13073-015-0147-1

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