Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite Formation In Vitro

Rapamycin is an antifungal agent with immunosuppressive properties. Rapamycin inhibits the mammalian target of rapamycin (mTOR) by blocking the mTOR complex 1 (mTORC1). mTOR is an atypical serine/threonine protein kinase, which controls cell growth, cell proliferation, and cell metabolism. However,...

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Detalles Bibliográficos
Autores principales: Leitmeyer, Katharina, Glutz, Andrea, Radojevic, Vesna, Setz, Cristian, Huerzeler, Nathan, Bumann, Helen, Bodmer, Daniel, Brand, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395993/
https://www.ncbi.nlm.nih.gov/pubmed/25918725
http://dx.doi.org/10.1155/2015/925890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395993/
https://www.ncbi.nlm.nih.gov/pubmed/25918725
http://dx.doi.org/10.1155/2015/925890

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