Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics

BACKGROUND: Gastrointestinal stromal tumours (GIST) are mainly characterised by the presence of activating mutations in either of the two receptor tyrosine kinases c-KIT or platelet-derived growth factor receptor-α (PDGFRα). Most mechanistic studies dealing with GIST mutations have focused on c-KIT...

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Detalles Bibliográficos
Autores principales: Bahlawane, Christelle, Eulenfeld, René, Wiesinger, Monique Y, Wang, Jiali, Muller, Arnaud, Girod, Andreas, Nazarov, Petr V, Felsch, Kathrin, Vallar, Laurent, Sauter, Thomas, Satagopam, Venkata P, Haan, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396151/
https://www.ncbi.nlm.nih.gov/pubmed/25880691
http://dx.doi.org/10.1186/s12964-015-0096-8

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