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Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood

We have investigated early programming of body mass in order to understand the multifactorial etiology of obesity. Considering that the renin-angiotensin system (RAS) is expressed and functional in the white adipose tissue (WAT) and modulates its development, we reasoned whether early transitory inh...

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Autores principales: de Picoli Souza, Kely, da Silva, Elton D., Batista, Elice C., Reis, Felipe C. G., Silva, Sylvia M. A., Castro, Charlles H. M., Luz, Jaqueline, Pesquero, Jorge L., dos Santos, Edson L., Pesquero, João B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396349/
https://www.ncbi.nlm.nih.gov/pubmed/25926796
http://dx.doi.org/10.3389/fphar.2015.00075
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author de Picoli Souza, Kely
da Silva, Elton D.
Batista, Elice C.
Reis, Felipe C. G.
Silva, Sylvia M. A.
Castro, Charlles H. M.
Luz, Jaqueline
Pesquero, Jorge L.
dos Santos, Edson L.
Pesquero, João B.
author_facet de Picoli Souza, Kely
da Silva, Elton D.
Batista, Elice C.
Reis, Felipe C. G.
Silva, Sylvia M. A.
Castro, Charlles H. M.
Luz, Jaqueline
Pesquero, Jorge L.
dos Santos, Edson L.
Pesquero, João B.
author_sort de Picoli Souza, Kely
collection PubMed
description We have investigated early programming of body mass in order to understand the multifactorial etiology of obesity. Considering that the renin-angiotensin system (RAS) is expressed and functional in the white adipose tissue (WAT) and modulates its development, we reasoned whether early transitory inhibition of angiotensin-I converting enzyme activity after birth could modify late body mass development. Therefore, newborn Wistar rats were treated with enalapril (10 mg/kg of body mass) or saline, starting at the first day of life until the age of 16 days. Between days ninetieth and hundred and eightieth, a group of these animals received high fat diet (HFD). Molecular, biochemical, histological, and physiological data were collected. Enalapril treated animals presented hyperphagia, overweight, and increased serum level of triglycerides, total cholesterol and leptin, in adult life. Body composition analyses revealed higher fat mass with increased adipocyte size in these animals. Molecular analyses revealed that enalapril treatment increases neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART) gene expression in hypothalamus, fatty acid synthase (FAS), and hormone-sensitive lipase (HSL) gene expression in retroperitoneal WAT, and decreases peroxixome proliferators-activated receptor (PPAR)γ, PPARα, uncoupling protein (UCP)2, and UCP3 gene expression in WAT. The results of the current study indicate that enalapril administration during early postnatal development increases body mass, adiposity and serum lipids in adulthood associated with enhanced food intake and decreased metabolic activity in WAT, predisposing to obesity in adulthood.
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spelling pubmed-43963492015-04-29 Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood de Picoli Souza, Kely da Silva, Elton D. Batista, Elice C. Reis, Felipe C. G. Silva, Sylvia M. A. Castro, Charlles H. M. Luz, Jaqueline Pesquero, Jorge L. dos Santos, Edson L. Pesquero, João B. Front Pharmacol Pharmacology We have investigated early programming of body mass in order to understand the multifactorial etiology of obesity. Considering that the renin-angiotensin system (RAS) is expressed and functional in the white adipose tissue (WAT) and modulates its development, we reasoned whether early transitory inhibition of angiotensin-I converting enzyme activity after birth could modify late body mass development. Therefore, newborn Wistar rats were treated with enalapril (10 mg/kg of body mass) or saline, starting at the first day of life until the age of 16 days. Between days ninetieth and hundred and eightieth, a group of these animals received high fat diet (HFD). Molecular, biochemical, histological, and physiological data were collected. Enalapril treated animals presented hyperphagia, overweight, and increased serum level of triglycerides, total cholesterol and leptin, in adult life. Body composition analyses revealed higher fat mass with increased adipocyte size in these animals. Molecular analyses revealed that enalapril treatment increases neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART) gene expression in hypothalamus, fatty acid synthase (FAS), and hormone-sensitive lipase (HSL) gene expression in retroperitoneal WAT, and decreases peroxixome proliferators-activated receptor (PPAR)γ, PPARα, uncoupling protein (UCP)2, and UCP3 gene expression in WAT. The results of the current study indicate that enalapril administration during early postnatal development increases body mass, adiposity and serum lipids in adulthood associated with enhanced food intake and decreased metabolic activity in WAT, predisposing to obesity in adulthood. Frontiers Media S.A. 2015-04-14 /pmc/articles/PMC4396349/ /pubmed/25926796 http://dx.doi.org/10.3389/fphar.2015.00075 Text en Copyright © 2015 de Picoli Souza, da Silva, Batista, Reis, Silva, Castro, Luz, Pesquero, dos Santos and Pesquero. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
de Picoli Souza, Kely
da Silva, Elton D.
Batista, Elice C.
Reis, Felipe C. G.
Silva, Sylvia M. A.
Castro, Charlles H. M.
Luz, Jaqueline
Pesquero, Jorge L.
dos Santos, Edson L.
Pesquero, João B.
Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood
title Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood
title_full Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood
title_fullStr Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood
title_full_unstemmed Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood
title_short Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood
title_sort early pharmacological inhibition of angiotensin-i converting enzyme activity induces obesity in adulthood
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396349/
https://www.ncbi.nlm.nih.gov/pubmed/25926796
http://dx.doi.org/10.3389/fphar.2015.00075
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