Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

Accumulating evidence suggests that viruses play an important role in the development of diabetes. Although the diabetogenic encephalomyocarditis strain D virus induces diabetes in restricted lines of inbred mice, the susceptibility genes to virus-induced diabetes have not been identified. We report...

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Detalles Bibliográficos
Autores principales: Izumi, Kenichi, Mine, Keiichiro, Inoue, Yoshitaka, Teshima, Miho, Ogawa, Shuichiro, Kai, Yuji, Kurafuji, Toshinobu, Hirakawa, Kanako, Miyakawa, Daiki, Ikeda, Haruka, Inada, Akari, Hara, Manami, Yamada, Hisakata, Akashi, Koichi, Niho, Yoshiyuki, Ina, Keisuke, Kobayashi, Takashi, Yoshikai, Yasunobu, Anzai, Keizo, Yamashita, Teruo, Minagawa, Hiroko, Fujimoto, Shuji, Kurisaki, Hironori, Shimoda, Kazuya, Katsuta, Hitoshi, Nagafuchi, Seiho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396380/
https://www.ncbi.nlm.nih.gov/pubmed/25849081
http://dx.doi.org/10.1038/ncomms7748

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