Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia

Episodes of human immunodeficiency virus low-level viremia (LLV) are common in the clinical setting, but its association with antiretroviral therapy (ART) regimen and adherence remains unclear. Antiretroviral therapy adherence was evaluated in participants of the Research on Access to Care in the Ho...

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Autores principales: Konstantopoulos, Christina, Ribaudo, Heather, Ragland, Kathleen, Bangsberg, David R., Li, Jonathan Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396432/
https://www.ncbi.nlm.nih.gov/pubmed/25884007
http://dx.doi.org/10.1093/ofid/ofu119
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author Konstantopoulos, Christina
Ribaudo, Heather
Ragland, Kathleen
Bangsberg, David R.
Li, Jonathan Z.
author_facet Konstantopoulos, Christina
Ribaudo, Heather
Ragland, Kathleen
Bangsberg, David R.
Li, Jonathan Z.
author_sort Konstantopoulos, Christina
collection PubMed
description Episodes of human immunodeficiency virus low-level viremia (LLV) are common in the clinical setting, but its association with antiretroviral therapy (ART) regimen and adherence remains unclear. Antiretroviral therapy adherence was evaluated in participants of the Research on Access to Care in the Homeless cohort by unannounced pill counts. Factors associated with increased risk of LLV include treatment with a protease inhibitor (PI)-based regimen (ritonavir-boosted PI vs nonnucleoside reverse-transcriptase inhibitor: adjusted hazard ratio [HR], 3.1; P = .01) and lower ART adherence over the past 3 months (HR, 1.1 per 5% decreased adherence, adjusted; P = .050). Patients with LLV may benefit from ART adherence counseling and potentially regimen modification.
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spelling pubmed-43964322015-04-16 Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia Konstantopoulos, Christina Ribaudo, Heather Ragland, Kathleen Bangsberg, David R. Li, Jonathan Z. Open Forum Infect Dis Brief Reports Episodes of human immunodeficiency virus low-level viremia (LLV) are common in the clinical setting, but its association with antiretroviral therapy (ART) regimen and adherence remains unclear. Antiretroviral therapy adherence was evaluated in participants of the Research on Access to Care in the Homeless cohort by unannounced pill counts. Factors associated with increased risk of LLV include treatment with a protease inhibitor (PI)-based regimen (ritonavir-boosted PI vs nonnucleoside reverse-transcriptase inhibitor: adjusted hazard ratio [HR], 3.1; P = .01) and lower ART adherence over the past 3 months (HR, 1.1 per 5% decreased adherence, adjusted; P = .050). Patients with LLV may benefit from ART adherence counseling and potentially regimen modification. Oxford University Press 2015-01-14 /pmc/articles/PMC4396432/ /pubmed/25884007 http://dx.doi.org/10.1093/ofid/ofu119 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Konstantopoulos, Christina
Ribaudo, Heather
Ragland, Kathleen
Bangsberg, David R.
Li, Jonathan Z.
Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia
title Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia
title_full Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia
title_fullStr Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia
title_full_unstemmed Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia
title_short Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia
title_sort antiretroviral regimen and suboptimal medication adherence are associated with low-level human immunodeficiency virus viremia
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396432/
https://www.ncbi.nlm.nih.gov/pubmed/25884007
http://dx.doi.org/10.1093/ofid/ofu119
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