Targeting the hypoxia pathway to treat pancreatic cancer

The correlation between hypoxia and pancreatic cancer has long been discussed. Hao’s research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-...

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Detalles Bibliográficos
Autores principales: Erickson, Lori A, Highsmith, W Edward, Fei, Peiwen, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396576/
https://www.ncbi.nlm.nih.gov/pubmed/25897209
http://dx.doi.org/10.2147/DDDT.S80888
Descripción
Sumario:The correlation between hypoxia and pancreatic cancer has long been discussed. Hao’s research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao’s research team suggests it is a promising approach to target HIF-1 for the management of pancreatic cancer progression and invasion.

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