Cargando…

Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?

Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Its characteristic neuropathological features encompass the loss of dopaminergic neurons of the nigrostriatal system and the presence of Lewy bodies and Lewy neurites. These are intraneuronal and intraneuritic prot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zaltieri, Michela, Longhena, Francesca, Pizzi, Marina, Missale, Cristina, Spano, PierFranco, Bellucci, Arianna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396726/ https://www.ncbi.nlm.nih.gov/pubmed/25918668 http://dx.doi.org/10.1155/2015/108029

Ejemplares similares

The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy
por: Longhena, Francesca, et al.
Publicado: (2017)

Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease
por: Bellucci, Arianna, et al.
Publicado: (2011)

Correction: Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease
por: Bellucci, Arianna, et al.
Publicado: (2012)

Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?
por: Faustini, Gaia, et al.
Publicado: (2017)

Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson’s Disease: An In Situ Proximity Ligation Assay Study
por: Longhena, Francesca, et al.
Publicado: (2018)

Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease
por: Bellucci, Arianna, et al.
Publicado: (2020)

The End Is the Beginning: Parkinson’s Disease in the Light of Brain Imaging
por: Bellucci, Arianna, et al.
Publicado: (2017)

Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?
por: Brembati, Viviana, et al.
Publicado: (2023)

Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology
por: Longhena, Francesca, et al.
Publicado: (2019)

Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease
por: Brembati, Viviana, et al.
Publicado: (2023)

Study of alpha-synuclein fibrillation: state of the art and expectations
por: Longhena, Francesca, et al.
Publicado: (2019)

Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives
por: Bogale, Tizibt Ashine, et al.
Publicado: (2021)

Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells
por: Faustini, Gaia, et al.
Publicado: (2019)

The Role of Rab Proteins in Parkinson’s Disease Synaptopathy
por: Bellucci, Arianna, et al.
Publicado: (2022)

NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice
por: Parrella, Edoardo, et al.
Publicado: (2019)

Alpha‐Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction
por: Ponterio, Giulia, et al.
Publicado: (2022)

Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype
por: Faustini, Gaia, et al.
Publicado: (2022)

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization
por: Calogero, Alessandra Maria, et al.
Publicado: (2023)

PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson’s Disease
por: Li, Wen, et al.
Publicado: (2021)

Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s Disease
por: Lamonaca, Giulia, et al.
Publicado: (2020)

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia
por: Schulz-Schaeffer, Walter J.
Publicado: (2010)

Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: insights into Parkinson’s disease
por: Banks, Susan M.L., et al.
Publicado: (2020)

Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson’s disease
por: Phan, Jenny-Ann, et al.
Publicado: (2017)

Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates
por: Faustini, Gaia, et al.
Publicado: (2022)

Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes
por: Filippini, Alice, et al.
Publicado: (2020)

αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson's Disease?
por: Protter, David, et al.
Publicado: (2012)

Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
por: Risiglione, Pierpaolo, et al.
Publicado: (2021)

Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice
por: Casiraghi, Andrea, et al.
Publicado: (2022)

Mild Inflammatory Profile without Gliosis in the c-Rel Deficient Mouse Modeling a Late-Onset Parkinsonism
por: Porrini, Vanessa, et al.
Publicado: (2017)

Exogenous Alpha-Synuclein Evoked Parkin Downregulation Promotes Mitochondrial Dysfunction in Neuronal Cells. Implications for Parkinson’s Disease Pathology
por: Wilkaniec, Anna, et al.
Publicado: (2021)

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration
por: Ghiglieri, Veronica, et al.
Publicado: (2018)

Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease
por: Fonseca-Ornelas, Luis, et al.
Publicado: (2021)

Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
por: Calabresi, Paolo, et al.
Publicado: (2023)

Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes
por: Indrieri, Alessia, et al.
Publicado: (2020)

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease
por: Bender, Andreas, et al.
Publicado: (2013)

NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases
por: Lanzillotta, Annamaria, et al.
Publicado: (2015)

Alpha-Synuclein Pathology and the Role of the Microbiota in Parkinson’s Disease
por: Fitzgerald, Emily, et al.
Publicado: (2019)

Initiation and progression of α-synuclein pathology in Parkinson’s disease
por: Tofaris, George K.
Publicado: (2022)

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
por: Zambon, Federico, et al.
Publicado: (2019)

LPS-induced mitochondrial dysfunction regulates innate immunity activation and α-synuclein oligomerization in Parkinson's disease
por: Esteves, A. Raquel, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3o5g5j874h74lgutm2o6foggla