Cargando…

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

BACKGROUND: Evidence from clinical studies and preclinical animal models suggests that proinflammatory cytokine overproduction is a potential driving force for pathology progression in traumatic brain injury (TBI). This raises the possibility that selective targeting of the overactive cytokine respo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bachstetter, Adam D, Webster, Scott J, Goulding, Danielle S, Morton, Jonathan E, Watterson, D Martin, Van Eldik, Linda J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396836/ https://www.ncbi.nlm.nih.gov/pubmed/25886256 http://dx.doi.org/10.1186/s12974-015-0289-5

Ejemplares similares

Generation and Behavior Characterization of CaMKIIβ Knockout Mice
por: Bachstetter, Adam D., et al.
Publicado: (2014)

Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia
por: Braun, David J., et al.
Publicado: (2019)

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes
por: Zhou, Zhengqiu, et al.
Publicado: (2017)

MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses
por: Bachstetter, Adam D., et al.
Publicado: (2016)

Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors
por: Bachstetter, Adam D., et al.
Publicado: (2014)

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
por: Bachstetter, Adam D, et al.
Publicado: (2011)

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury
por: Lloyd, Eric, et al.
Publicado: (2008)

Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models
por: Xing, Bin, et al.
Publicado: (2013)

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism
por: Bachstetter, Adam D, et al.
Publicado: (2014)

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease
por: Webster, Scott J, et al.
Publicado: (2013)

Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain
por: Bachstetter, Adam D, et al.
Publicado: (2013)

A blunted T(H)17 cytokine signature in women with mild cognitive impairment: insights from inflammatory profiling of a community-based cohort of older adults
por: Bachstetter, Adam D, et al.
Publicado: (2023)

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice
por: Early, Alexandria N., et al.
Publicado: (2020)

Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism
por: Bodnar, Colleen N., et al.
Publicado: (2018)

Diffuse Brain Injury Induces Acute Post-Traumatic Sleep
por: Rowe, Rachel K., et al.
Publicado: (2014)

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models
por: Roy, Saktimayee M., et al.
Publicado: (2015)

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
por: Webster, Scott J., et al.
Publicado: (2014)

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
por: Xing, Bin, et al.
Publicado: (2011)

Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults
por: Xing, Bin, et al.
Publicado: (2014)

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction
por: Roy, Saktimayee M., et al.
Publicado: (2019)

Correction to “A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction”
por: Roy, Saktimayee M., et al.
Publicado: (2020)

A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model
por: Munoz, Lenka, et al.
Publicado: (2007)

Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice
por: Morganti, Josh M., et al.
Publicado: (2019)

Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology
por: Braun, David J., et al.
Publicado: (2022)

Nonoxid-HMGB1 Attenuates Cognitive Impairment After Traumatic Brain Injury in Rats
por: Chen, Jun-Quan, et al.
Publicado: (2022)

Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge
por: Rowe, Rachel K, et al.
Publicado: (2016)

Trehalose improves traumatic brain injury-induced cognitive impairment
por: Portbury, Stuart D., et al.
Publicado: (2017)

Disconnection of network hubs and cognitive impairment after traumatic brain injury
por: Fagerholm, Erik D., et al.
Publicado: (2015)

Propofol attenuates the neuroprotective effects of magnesium in experimental traumatic brain injury
por: Aktan, D, et al.
Publicado: (2002)

The p38α mitogen-activated protein kinase as a central nervous system drug discovery target
por: Borders, Aaron S, et al.
Publicado: (2008)

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid
por: Craft, Jeffrey M, et al.
Publicado: (2005)

Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments
por: Allen, Barrett D., et al.
Publicado: (2019)

Artesunate attenuates traumatic brain injury-induced impairments in rats
por: Zhou, Zhike, et al.
Publicado: (2020)

Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat
por: Liu, Tao, et al.
Publicado: (2016)

Xuefu zhuyu decoction improves cognitive impairment in experimental traumatic brain injury via synaptic regulation
por: Zhou, Jing, et al.
Publicado: (2017)

Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging
por: Bachstetter, Adam D., et al.
Publicado: (2015)

Cognitive reappraisal and nasal cytokine production following experimental rhinovirus infection
por: Brown, Ryan L., et al.
Publicado: (2019)

A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism
por: Lyons, Danielle N., et al.
Publicado: (2018)

A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats
por: Bodnar, Colleen N., et al.
Publicado: (2019)

Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury
por: Pu, Hongjian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_a1jsmki5hkac6haenvume32t41