55.2, a Phage T4 ORFan Gene, Encodes an Inhibitor of Escherichia coli Topoisomerase I and Increases Phage Fitness

Topoisomerases are enzymes that alter the topological properties of DNA. Phage T4 encodes its own topoisomerase but it can also utilize host-encoded topoisomerases. Here we characterized 55.2, a phage T4 predicted ORF of unknown function. High levels of expression of the cloned 55.2 gene are toxic i...

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Detalles Bibliográficos
Autores principales: Mattenberger, Yves, Silva, Filo, Belin, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396842/
https://www.ncbi.nlm.nih.gov/pubmed/25875362
http://dx.doi.org/10.1371/journal.pone.0124309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396842/
https://www.ncbi.nlm.nih.gov/pubmed/25875362
http://dx.doi.org/10.1371/journal.pone.0124309

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