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55.2, a Phage T4 ORFan Gene, Encodes an Inhibitor of Escherichia coli Topoisomerase I and Increases Phage Fitness
Topoisomerases are enzymes that alter the topological properties of DNA. Phage T4 encodes its own topoisomerase but it can also utilize host-encoded topoisomerases. Here we characterized 55.2, a phage T4 predicted ORF of unknown function. High levels of expression of the cloned 55.2 gene are toxic i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396842/ https://www.ncbi.nlm.nih.gov/pubmed/25875362 http://dx.doi.org/10.1371/journal.pone.0124309 |