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Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis
Tunicates have high capacities for regeneration but the underlying mechanisms and their relationship to life cycle progression are not well understood. Here we investigate the regeneration of distal structures in the ascidian tunicate Ciona intestinalis. Analysis of regenerative potential along the...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396878/ https://www.ncbi.nlm.nih.gov/pubmed/25893097 http://dx.doi.org/10.1002/reg2.26 |
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author | Jeffery, William R. |
author_facet | Jeffery, William R. |
author_sort | Jeffery, William R. |
collection | PubMed |
description | Tunicates have high capacities for regeneration but the underlying mechanisms and their relationship to life cycle progression are not well understood. Here we investigate the regeneration of distal structures in the ascidian tunicate Ciona intestinalis. Analysis of regenerative potential along the proximal−distal body axis indicated that distal organs, such as the siphons, their pigmented sensory organs, and the neural complex, could only be replaced from body fragments containing the branchial sac. Distal regeneration involves the formation of a blastema composed of cells that undergo cell proliferation prior to differentiation and cells that differentiate without cell proliferation. Both cell types originate in the branchial sac and appear in the blastema at different times after distal injury. Whereas the branchial sac stem cells are present in young animals, they are depleted in old animals that have lost their regeneration capacity. Thus Ciona adults contain a population of age‐related stem cells located in the branchial sac that are a source of precursors for distal body regeneration. |
format | Online Article Text |
id | pubmed-4396878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43968782016-01-31 Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis Jeffery, William R. Regeneration (Oxf) Research Articles Tunicates have high capacities for regeneration but the underlying mechanisms and their relationship to life cycle progression are not well understood. Here we investigate the regeneration of distal structures in the ascidian tunicate Ciona intestinalis. Analysis of regenerative potential along the proximal−distal body axis indicated that distal organs, such as the siphons, their pigmented sensory organs, and the neural complex, could only be replaced from body fragments containing the branchial sac. Distal regeneration involves the formation of a blastema composed of cells that undergo cell proliferation prior to differentiation and cells that differentiate without cell proliferation. Both cell types originate in the branchial sac and appear in the blastema at different times after distal injury. Whereas the branchial sac stem cells are present in young animals, they are depleted in old animals that have lost their regeneration capacity. Thus Ciona adults contain a population of age‐related stem cells located in the branchial sac that are a source of precursors for distal body regeneration. John Wiley and Sons Inc. 2014-11-13 /pmc/articles/PMC4396878/ /pubmed/25893097 http://dx.doi.org/10.1002/reg2.26 Text en © 2014 The Authors. Regeneration published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Jeffery, William R. Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis |
title | Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis
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title_full | Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis
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title_fullStr | Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis
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title_full_unstemmed | Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis
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title_short | Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis
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title_sort | distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian ciona intestinalis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396878/ https://www.ncbi.nlm.nih.gov/pubmed/25893097 http://dx.doi.org/10.1002/reg2.26 |
work_keys_str_mv | AT jefferywilliamr distalregenerationinvolvestheagedependentactivityofbranchialsacstemcellsintheascidiancionaintestinalis |