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Has Madagascar Lost Its Exceptional Leptospirosis Free-Like Status?
BACKGROUND: Leptospirosis is a widespread but underreported cause of morbidity and mortality. It has rarely been reported in either humans or animals in Madagascar. METHODS: We conducted a cross-sectional survey of the inhabitants in Moramanga, Madagascar, in June 2011, to estimate the prevalence of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396993/ https://www.ncbi.nlm.nih.gov/pubmed/25874381 http://dx.doi.org/10.1371/journal.pone.0122683 |
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author | Ratsitorahina, Maherisoa Rahelinirina, Soanandrasana Michault, Alain Rajerison, Minoarisoa Rajatonirina, Soatiana Richard, Vincent |
author_facet | Ratsitorahina, Maherisoa Rahelinirina, Soanandrasana Michault, Alain Rajerison, Minoarisoa Rajatonirina, Soatiana Richard, Vincent |
author_sort | Ratsitorahina, Maherisoa |
collection | PubMed |
description | BACKGROUND: Leptospirosis is a widespread but underreported cause of morbidity and mortality. It has rarely been reported in either humans or animals in Madagascar. METHODS: We conducted a cross-sectional survey of the inhabitants in Moramanga, Madagascar, in June 2011, to estimate the prevalence of human infection using the microscopic agglutination test (MAT). This activity was carried out as part of a workshop implemented by the Pasteur Institute of Madagascar, focusing on surveillance with a one week field study and targeting the health staff of the district level. RESULTS: In total, we sampled 678 inhabitants from 263 households. The sex ratio (M/F) was 0.65 and the mean age 26.7 years. We obtained a value of 2.9% for the first recorded seroprevalence of this disease in the human community of Moramanga. Questionnaire responses revealed frequent contacts between humans and rodents in Moramanga. However, activities involving cattle were identified as a risk factor significantly associated with seropositivity (OR=3). CONCLUSION: Leptospirosis remains a neglected disease in Madagascar. This study highlights the need to quantify the public health impact of this neglected disease in a more large scale, in all the country and to establish point-of-care laboratories in remote areas. |
format | Online Article Text |
id | pubmed-4396993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43969932015-04-21 Has Madagascar Lost Its Exceptional Leptospirosis Free-Like Status? Ratsitorahina, Maherisoa Rahelinirina, Soanandrasana Michault, Alain Rajerison, Minoarisoa Rajatonirina, Soatiana Richard, Vincent PLoS One Research Article BACKGROUND: Leptospirosis is a widespread but underreported cause of morbidity and mortality. It has rarely been reported in either humans or animals in Madagascar. METHODS: We conducted a cross-sectional survey of the inhabitants in Moramanga, Madagascar, in June 2011, to estimate the prevalence of human infection using the microscopic agglutination test (MAT). This activity was carried out as part of a workshop implemented by the Pasteur Institute of Madagascar, focusing on surveillance with a one week field study and targeting the health staff of the district level. RESULTS: In total, we sampled 678 inhabitants from 263 households. The sex ratio (M/F) was 0.65 and the mean age 26.7 years. We obtained a value of 2.9% for the first recorded seroprevalence of this disease in the human community of Moramanga. Questionnaire responses revealed frequent contacts between humans and rodents in Moramanga. However, activities involving cattle were identified as a risk factor significantly associated with seropositivity (OR=3). CONCLUSION: Leptospirosis remains a neglected disease in Madagascar. This study highlights the need to quantify the public health impact of this neglected disease in a more large scale, in all the country and to establish point-of-care laboratories in remote areas. Public Library of Science 2015-04-14 /pmc/articles/PMC4396993/ /pubmed/25874381 http://dx.doi.org/10.1371/journal.pone.0122683 Text en © 2015 Ratsitorahina et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Ratsitorahina, Maherisoa Rahelinirina, Soanandrasana Michault, Alain Rajerison, Minoarisoa Rajatonirina, Soatiana Richard, Vincent Has Madagascar Lost Its Exceptional Leptospirosis Free-Like Status? |
title | Has Madagascar Lost Its Exceptional Leptospirosis Free-Like Status? |
title_full | Has Madagascar Lost Its Exceptional Leptospirosis Free-Like Status? |
title_fullStr | Has Madagascar Lost Its Exceptional Leptospirosis Free-Like Status? |
title_full_unstemmed | Has Madagascar Lost Its Exceptional Leptospirosis Free-Like Status? |
title_short | Has Madagascar Lost Its Exceptional Leptospirosis Free-Like Status? |
title_sort | has madagascar lost its exceptional leptospirosis free-like status? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396993/ https://www.ncbi.nlm.nih.gov/pubmed/25874381 http://dx.doi.org/10.1371/journal.pone.0122683 |
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