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Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141

Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I degradation. A systematic proteomic study usi...

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Detalles Bibliográficos
Autores principales:	Hsu, Jye-Lin, van den Boomen, Dick J. H., Tomasec, Peter, Weekes, Michael P., Antrobus, Robin, Stanton, Richard J., Ruckova, Eva, Sugrue, Daniel, Wilkie, Gavin S., Davison, Andrew J., Wilkinson, Gavin W. G., Lehner, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397069/ https://www.ncbi.nlm.nih.gov/pubmed/25875600 http://dx.doi.org/10.1371/journal.ppat.1004811

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