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Insulin Reverses D-Glucose–Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells

Vascular tone is controlled by the L-arginine/nitric oxide (NO) pathway, and NO bioavailability is strongly affected by hyperglycaemia-induced oxidative stress. Insulin leads to high expression and activity of human cationic amino acid transporter 1 (hCAT-1), NO synthesis and vasodilation; thus, a p...

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Detalles Bibliográficos
Autores principales:	González, Marcelo, Rojas, Susana, Avila, Pía, Cabrera, Lissette, Villalobos, Roberto, Palma, Carlos, Aguayo, Claudio, Peña, Eduardo, Gallardo, Victoria, Guzmán-Gutiérrez, Enrique, Sáez, Tamara, Salsoso, Rocío, Sanhueza, Carlos, Pardo, Fabián, Leiva, Andrea, Sobrevia, Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397070/ https://www.ncbi.nlm.nih.gov/pubmed/25875935 http://dx.doi.org/10.1371/journal.pone.0122398

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