Cargando…

Case-control study of ADARB1 and ADARB2 gene variants in migraine

BACKGROUND: Migraine causes crippling attacks of severe head pain along with associated nausea, vomiting, photophobia and/or phonophobia. The aim of this study was to investigate single nucleotide polymorphisms (SNPs) in the adenosine deaminase, RNA-specific, B1 (ADARB1) and adenosine deaminase, RNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Gasparini, Claudia F, Sutherland, Heidi G, Maher, Bridget, Rodriguez-Acevedo, Astrid J, Khlifi, Elhame, Haupt, Larisa M, Griffiths, Lyn R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397221/
https://www.ncbi.nlm.nih.gov/pubmed/25916332
http://dx.doi.org/10.1186/s10194-015-0511-y
_version_ 1782366678444670976
author Gasparini, Claudia F
Sutherland, Heidi G
Maher, Bridget
Rodriguez-Acevedo, Astrid J
Khlifi, Elhame
Haupt, Larisa M
Griffiths, Lyn R
author_facet Gasparini, Claudia F
Sutherland, Heidi G
Maher, Bridget
Rodriguez-Acevedo, Astrid J
Khlifi, Elhame
Haupt, Larisa M
Griffiths, Lyn R
author_sort Gasparini, Claudia F
collection PubMed
description BACKGROUND: Migraine causes crippling attacks of severe head pain along with associated nausea, vomiting, photophobia and/or phonophobia. The aim of this study was to investigate single nucleotide polymorphisms (SNPs) in the adenosine deaminase, RNA-specific, B1 (ADARB1) and adenosine deaminase, RNA specific, B2 (ADARB2) genes in an Australian case–control Caucasian population for association with migraine. Both candidate genes are highly expressed in the central nervous system and fit criteria for migraine neuropathology. SNPs in the ADARB2 gene were previously found to be positively associated with migraine in a pedigree-based genome wide association study using the genetic isolate of Norfolk Island, Australia. The ADARB1 gene was also chosen for investigation due to its important function in editing neurotransmitter receptor transcripts. METHODS: Four SNPs in ADARB1 and nine in ADARB2 were selected by inspecting blocks of linkage disequilibrium in Haploview for genotyping using either TaqMan or Sequenom assays. These SNPs were genotyped in two-hundred and ninety one patients who satisfied the International Classification of Headache Disorders-II 2004 diagnostic criteria for migraine, and three-hundred and fourteen controls, and PLINK was used for association testing. RESULTS: Chi-square analysis found no significant association between any of the SNPs tested in the ADARB1 and ADARB2 genes in this study and the occurrence of migraine. CONCLUSIONS: In contrast to findings that SNPs in the ADARB2 gene were positively associated with migraine in the Norfolk Island population, we find no evidence to support the involvement of RNA editing genes in migraine susceptibility in an Australian Caucasian population.
format Online
Article
Text
id pubmed-4397221
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer Milan
record_format MEDLINE/PubMed
spelling pubmed-43972212015-04-20 Case-control study of ADARB1 and ADARB2 gene variants in migraine Gasparini, Claudia F Sutherland, Heidi G Maher, Bridget Rodriguez-Acevedo, Astrid J Khlifi, Elhame Haupt, Larisa M Griffiths, Lyn R J Headache Pain Research Article BACKGROUND: Migraine causes crippling attacks of severe head pain along with associated nausea, vomiting, photophobia and/or phonophobia. The aim of this study was to investigate single nucleotide polymorphisms (SNPs) in the adenosine deaminase, RNA-specific, B1 (ADARB1) and adenosine deaminase, RNA specific, B2 (ADARB2) genes in an Australian case–control Caucasian population for association with migraine. Both candidate genes are highly expressed in the central nervous system and fit criteria for migraine neuropathology. SNPs in the ADARB2 gene were previously found to be positively associated with migraine in a pedigree-based genome wide association study using the genetic isolate of Norfolk Island, Australia. The ADARB1 gene was also chosen for investigation due to its important function in editing neurotransmitter receptor transcripts. METHODS: Four SNPs in ADARB1 and nine in ADARB2 were selected by inspecting blocks of linkage disequilibrium in Haploview for genotyping using either TaqMan or Sequenom assays. These SNPs were genotyped in two-hundred and ninety one patients who satisfied the International Classification of Headache Disorders-II 2004 diagnostic criteria for migraine, and three-hundred and fourteen controls, and PLINK was used for association testing. RESULTS: Chi-square analysis found no significant association between any of the SNPs tested in the ADARB1 and ADARB2 genes in this study and the occurrence of migraine. CONCLUSIONS: In contrast to findings that SNPs in the ADARB2 gene were positively associated with migraine in the Norfolk Island population, we find no evidence to support the involvement of RNA editing genes in migraine susceptibility in an Australian Caucasian population. Springer Milan 2015-04-03 /pmc/articles/PMC4397221/ /pubmed/25916332 http://dx.doi.org/10.1186/s10194-015-0511-y Text en © Gaspirini et al.; licensee Springer. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Gasparini, Claudia F
Sutherland, Heidi G
Maher, Bridget
Rodriguez-Acevedo, Astrid J
Khlifi, Elhame
Haupt, Larisa M
Griffiths, Lyn R
Case-control study of ADARB1 and ADARB2 gene variants in migraine
title Case-control study of ADARB1 and ADARB2 gene variants in migraine
title_full Case-control study of ADARB1 and ADARB2 gene variants in migraine
title_fullStr Case-control study of ADARB1 and ADARB2 gene variants in migraine
title_full_unstemmed Case-control study of ADARB1 and ADARB2 gene variants in migraine
title_short Case-control study of ADARB1 and ADARB2 gene variants in migraine
title_sort case-control study of adarb1 and adarb2 gene variants in migraine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397221/
https://www.ncbi.nlm.nih.gov/pubmed/25916332
http://dx.doi.org/10.1186/s10194-015-0511-y
work_keys_str_mv AT gaspariniclaudiaf casecontrolstudyofadarb1andadarb2genevariantsinmigraine
AT sutherlandheidig casecontrolstudyofadarb1andadarb2genevariantsinmigraine
AT maherbridget casecontrolstudyofadarb1andadarb2genevariantsinmigraine
AT rodriguezacevedoastridj casecontrolstudyofadarb1andadarb2genevariantsinmigraine
AT khlifielhame casecontrolstudyofadarb1andadarb2genevariantsinmigraine
AT hauptlarisam casecontrolstudyofadarb1andadarb2genevariantsinmigraine
AT griffithslynr casecontrolstudyofadarb1andadarb2genevariantsinmigraine