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Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus

PURPOSE: Although microalbuminuria is considered as an early marker of nephropathy in diabetic adults, available information in diabetic adolescents is limited. The aim of this study was to investigate prevalence and frequency of regression of microalbuminuria in type 1 (T1DM) and type 2 diabetes me...

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Autores principales: Son, Mi Kyung, Yoo, Ha Young, Kwak, Byung Ok, Park, Hye Won, Kim, Kyo Sun, Chung, Sochung, Chae, Hyun Wook, Kim, Ho-Seong, Kim, Duk Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pediatric Endocrinology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397268/
https://www.ncbi.nlm.nih.gov/pubmed/25883922
http://dx.doi.org/10.6065/apem.2015.20.1.13
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author Son, Mi Kyung
Yoo, Ha Young
Kwak, Byung Ok
Park, Hye Won
Kim, Kyo Sun
Chung, Sochung
Chae, Hyun Wook
Kim, Ho-Seong
Kim, Duk Hee
author_facet Son, Mi Kyung
Yoo, Ha Young
Kwak, Byung Ok
Park, Hye Won
Kim, Kyo Sun
Chung, Sochung
Chae, Hyun Wook
Kim, Ho-Seong
Kim, Duk Hee
author_sort Son, Mi Kyung
collection PubMed
description PURPOSE: Although microalbuminuria is considered as an early marker of nephropathy in diabetic adults, available information in diabetic adolescents is limited. The aim of this study was to investigate prevalence and frequency of regression of microalbuminuria in type 1 (T1DM) and type 2 diabetes mellitus (T2DM) patients with childhood onset. METHODS: One hundred and nine adolescents (median, 18.9 years; interquartile range (IQR), 16.5-21.0 years) with T1DM and 18 T2DM adolescents (median, 17.9 years; IQR, 16.8-18.4 years) with repeated measurements of microalbuminuria (first morning urine microalbumin/creatinine ratios) were included. The median duration of diabetes was 10.1 (7.8-14.0) years and 5.0 (3.5-5.6) years, respectively, and follow-up period ranged 0.5-7.0 years. Growth parameters, estimated glomerular filtration rate, glycosylated hemoglobin (HbA1c) and lipid profiles were obtained after reviewing medical record in each subject. RESULTS: The prevalence of microalbuminuria at baseline and evaluation were 21.1% and 17.4% in T1DM, and 44.4% and 38.9% in T2DM. Regression of microalbuminuria was observed in 13 T1DM patients (56.5%) and 3 T2DM patients (37.5%), and progression rate was 10.5% and 20% in T1DM and T2DM respectively. In regression T1DM group, HbA1c at baseline and follow-up was lower, and C-peptide at baseline was higher compared to persistent or progression groups. In T2DM, higher triglyceride was observed in persistent group. CONCLUSION: Considerable regression of microalbuminuria more than progression in diabetes adolescents indicates elevated urinary microalbumin excretion in a single test does not imply irreversible diabetic nephropathy. Careful monitoring and adequate intervention should be emphasized in adolescents with microalbuminuria to prevent rapid progression toward diabetic nephropathy.
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spelling pubmed-43972682015-04-16 Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus Son, Mi Kyung Yoo, Ha Young Kwak, Byung Ok Park, Hye Won Kim, Kyo Sun Chung, Sochung Chae, Hyun Wook Kim, Ho-Seong Kim, Duk Hee Ann Pediatr Endocrinol Metab Original Article PURPOSE: Although microalbuminuria is considered as an early marker of nephropathy in diabetic adults, available information in diabetic adolescents is limited. The aim of this study was to investigate prevalence and frequency of regression of microalbuminuria in type 1 (T1DM) and type 2 diabetes mellitus (T2DM) patients with childhood onset. METHODS: One hundred and nine adolescents (median, 18.9 years; interquartile range (IQR), 16.5-21.0 years) with T1DM and 18 T2DM adolescents (median, 17.9 years; IQR, 16.8-18.4 years) with repeated measurements of microalbuminuria (first morning urine microalbumin/creatinine ratios) were included. The median duration of diabetes was 10.1 (7.8-14.0) years and 5.0 (3.5-5.6) years, respectively, and follow-up period ranged 0.5-7.0 years. Growth parameters, estimated glomerular filtration rate, glycosylated hemoglobin (HbA1c) and lipid profiles were obtained after reviewing medical record in each subject. RESULTS: The prevalence of microalbuminuria at baseline and evaluation were 21.1% and 17.4% in T1DM, and 44.4% and 38.9% in T2DM. Regression of microalbuminuria was observed in 13 T1DM patients (56.5%) and 3 T2DM patients (37.5%), and progression rate was 10.5% and 20% in T1DM and T2DM respectively. In regression T1DM group, HbA1c at baseline and follow-up was lower, and C-peptide at baseline was higher compared to persistent or progression groups. In T2DM, higher triglyceride was observed in persistent group. CONCLUSION: Considerable regression of microalbuminuria more than progression in diabetes adolescents indicates elevated urinary microalbumin excretion in a single test does not imply irreversible diabetic nephropathy. Careful monitoring and adequate intervention should be emphasized in adolescents with microalbuminuria to prevent rapid progression toward diabetic nephropathy. The Korean Society of Pediatric Endocrinology 2015-03 2015-03-31 /pmc/articles/PMC4397268/ /pubmed/25883922 http://dx.doi.org/10.6065/apem.2015.20.1.13 Text en © 2015 Annals of Pediatric Endocrinology & Metabolism http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Son, Mi Kyung
Yoo, Ha Young
Kwak, Byung Ok
Park, Hye Won
Kim, Kyo Sun
Chung, Sochung
Chae, Hyun Wook
Kim, Ho-Seong
Kim, Duk Hee
Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus
title Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus
title_full Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus
title_fullStr Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus
title_full_unstemmed Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus
title_short Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus
title_sort regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397268/
https://www.ncbi.nlm.nih.gov/pubmed/25883922
http://dx.doi.org/10.6065/apem.2015.20.1.13
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