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Pregnancy Outcomes in Women with Moyamoya Disease: Experiences at a Single Center in Korea

PURPOSE: Moyamoya disease (MMD) occurs predominantly in Korean and Japanese women. The aim of this study was to investigate clinical features and pregnancy outcomes in women with MMD. MATERIALS AND METHODS: We conducted a retrospective chart review of women with MMD who visited our Department of Obs...

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Autores principales: Jung, Yun Ji, Kim, Min-A, Kwon, Ja-Young, Lee, Hyo Ryun, Cho, Hee Young, Park, Yong Won, Kim, Young Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397451/
https://www.ncbi.nlm.nih.gov/pubmed/25837187
http://dx.doi.org/10.3349/ymj.2015.56.3.793
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author Jung, Yun Ji
Kim, Min-A
Kwon, Ja-Young
Lee, Hyo Ryun
Cho, Hee Young
Park, Yong Won
Kim, Young Han
author_facet Jung, Yun Ji
Kim, Min-A
Kwon, Ja-Young
Lee, Hyo Ryun
Cho, Hee Young
Park, Yong Won
Kim, Young Han
author_sort Jung, Yun Ji
collection PubMed
description PURPOSE: Moyamoya disease (MMD) occurs predominantly in Korean and Japanese women. The aim of this study was to investigate clinical features and pregnancy outcomes in women with MMD. MATERIALS AND METHODS: We conducted a retrospective chart review of women with MMD who visited our Department of Obstetrics and Gynecology between January 2005 and October 2013. For all study subjects, clinical features, demographic characteristics, and perinatal outcomes were recorded. RESULTS: We identified 28 pregnancies in 22 patients who had been diagnosed with MMD. The mean maternal age at delivery was 31.9±3.5 years old. The mean gestational age at delivery was 38.0±0.9 weeks. Among the 28 pregnancies, 25 (92.5%) underwent cesarean section; 19 (76.0%) of them were performed under regional anesthesia and six (24.0%) under general anesthesia. The mean newborn weight was 3233.7±348.2 g. The 5-minute Apgar score in 85% of the newborns was higher than 8, with no other apparent complications. During the puerperal period, transient ischemic attack symptom or seizure occurred in 4 cases, although patients recovered within a few days. CONCLUSION: For pregnant women with MMD, it is important to control blood pressure and prevent hyperventilation during the intrapartum period, and the best methods of delivery and anesthesia should be considered to avoid unfavorable sequelae. Additionally, a multidisciplinary approach (i.e., neurosurgery) is necessary to constantly manage underlying diseases.
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spelling pubmed-43974512015-05-01 Pregnancy Outcomes in Women with Moyamoya Disease: Experiences at a Single Center in Korea Jung, Yun Ji Kim, Min-A Kwon, Ja-Young Lee, Hyo Ryun Cho, Hee Young Park, Yong Won Kim, Young Han Yonsei Med J Original Article PURPOSE: Moyamoya disease (MMD) occurs predominantly in Korean and Japanese women. The aim of this study was to investigate clinical features and pregnancy outcomes in women with MMD. MATERIALS AND METHODS: We conducted a retrospective chart review of women with MMD who visited our Department of Obstetrics and Gynecology between January 2005 and October 2013. For all study subjects, clinical features, demographic characteristics, and perinatal outcomes were recorded. RESULTS: We identified 28 pregnancies in 22 patients who had been diagnosed with MMD. The mean maternal age at delivery was 31.9±3.5 years old. The mean gestational age at delivery was 38.0±0.9 weeks. Among the 28 pregnancies, 25 (92.5%) underwent cesarean section; 19 (76.0%) of them were performed under regional anesthesia and six (24.0%) under general anesthesia. The mean newborn weight was 3233.7±348.2 g. The 5-minute Apgar score in 85% of the newborns was higher than 8, with no other apparent complications. During the puerperal period, transient ischemic attack symptom or seizure occurred in 4 cases, although patients recovered within a few days. CONCLUSION: For pregnant women with MMD, it is important to control blood pressure and prevent hyperventilation during the intrapartum period, and the best methods of delivery and anesthesia should be considered to avoid unfavorable sequelae. Additionally, a multidisciplinary approach (i.e., neurosurgery) is necessary to constantly manage underlying diseases. Yonsei University College of Medicine 2015-05-01 2015-04-01 /pmc/articles/PMC4397451/ /pubmed/25837187 http://dx.doi.org/10.3349/ymj.2015.56.3.793 Text en © Copyright: Yonsei University College of Medicine 2015 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jung, Yun Ji
Kim, Min-A
Kwon, Ja-Young
Lee, Hyo Ryun
Cho, Hee Young
Park, Yong Won
Kim, Young Han
Pregnancy Outcomes in Women with Moyamoya Disease: Experiences at a Single Center in Korea
title Pregnancy Outcomes in Women with Moyamoya Disease: Experiences at a Single Center in Korea
title_full Pregnancy Outcomes in Women with Moyamoya Disease: Experiences at a Single Center in Korea
title_fullStr Pregnancy Outcomes in Women with Moyamoya Disease: Experiences at a Single Center in Korea
title_full_unstemmed Pregnancy Outcomes in Women with Moyamoya Disease: Experiences at a Single Center in Korea
title_short Pregnancy Outcomes in Women with Moyamoya Disease: Experiences at a Single Center in Korea
title_sort pregnancy outcomes in women with moyamoya disease: experiences at a single center in korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397451/
https://www.ncbi.nlm.nih.gov/pubmed/25837187
http://dx.doi.org/10.3349/ymj.2015.56.3.793
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