The Role of Hyaluronan in Innate Defense Responses of the Intestine

Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this glycosaminoglycan can participate in regulating in...

Descripción completa

Detalles Bibliográficos
Autores principales: de la Motte, Carol A., Kessler, Sean P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397497/
https://www.ncbi.nlm.nih.gov/pubmed/25922605
http://dx.doi.org/10.1155/2015/481301
_version_ 1782366713046630400
author de la Motte, Carol A.
Kessler, Sean P.
author_facet de la Motte, Carol A.
Kessler, Sean P.
author_sort de la Motte, Carol A.
collection PubMed
description Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this glycosaminoglycan can participate in regulating innate host defense mechanisms. These natural responses include mechanisms promoting rapid leukocyte recruitment after bacterial challenge/colon tissue damage as well as promoting epithelial defense mechanisms in the intestine.
format Online
Article
Text
id pubmed-4397497
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-43974972015-04-28 The Role of Hyaluronan in Innate Defense Responses of the Intestine de la Motte, Carol A. Kessler, Sean P. Int J Cell Biol Review Article Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this glycosaminoglycan can participate in regulating innate host defense mechanisms. These natural responses include mechanisms promoting rapid leukocyte recruitment after bacterial challenge/colon tissue damage as well as promoting epithelial defense mechanisms in the intestine. Hindawi Publishing Corporation 2015 2015-03-30 /pmc/articles/PMC4397497/ /pubmed/25922605 http://dx.doi.org/10.1155/2015/481301 Text en Copyright © 2015 C. A. de la Motte and S. P. Kessler. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
de la Motte, Carol A.
Kessler, Sean P.
The Role of Hyaluronan in Innate Defense Responses of the Intestine
title The Role of Hyaluronan in Innate Defense Responses of the Intestine
title_full The Role of Hyaluronan in Innate Defense Responses of the Intestine
title_fullStr The Role of Hyaluronan in Innate Defense Responses of the Intestine
title_full_unstemmed The Role of Hyaluronan in Innate Defense Responses of the Intestine
title_short The Role of Hyaluronan in Innate Defense Responses of the Intestine
title_sort role of hyaluronan in innate defense responses of the intestine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397497/
https://www.ncbi.nlm.nih.gov/pubmed/25922605
http://dx.doi.org/10.1155/2015/481301
work_keys_str_mv AT delamottecarola theroleofhyaluronanininnatedefenseresponsesoftheintestine
AT kesslerseanp theroleofhyaluronanininnatedefenseresponsesoftheintestine
AT delamottecarola roleofhyaluronanininnatedefenseresponsesoftheintestine
AT kesslerseanp roleofhyaluronanininnatedefenseresponsesoftheintestine

Ejemplares similares