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Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation
PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases, through clinical genetics and gene disruption in mice. Novel, selective PAD4 inhibitors binding to a calcium-deficient form of the PAD4 enzyme have, for the first time, validated the critica...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397581/ https://www.ncbi.nlm.nih.gov/pubmed/25622091 http://dx.doi.org/10.1038/nchembio.1735 |
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| author | Lewis, Huw D. Liddle, John Coote, Jim E. Atkinson, Stephen J. Barker, Michael D. Bax, Benjamin, D. Bicker, Kevin L. Bingham, Ryan P. Campbell, Matthew Chen, Yu Hua Chung, Chun-wa Craggs, Peter D. Davis, Rob P. Eberhard, Dirk Joberty, Gerard Lind, Kenneth E. Locke, Kelly Maller, Claire Martinod, Kimberly Patten, Chris Polyakova, Oxana Rise, Cecil E. Rüdiger, Martin Sheppard, Robert J. Slade, Daniel J. Thomas, Pamela Thorpe, Jim Yao, Gang Drewes, Gerard Wagner, Denisa D. Thompson, Paul R. Prinjha, Rab K. Wilson, David M. |
| author_facet | Lewis, Huw D. Liddle, John Coote, Jim E. Atkinson, Stephen J. Barker, Michael D. Bax, Benjamin, D. Bicker, Kevin L. Bingham, Ryan P. Campbell, Matthew Chen, Yu Hua Chung, Chun-wa Craggs, Peter D. Davis, Rob P. Eberhard, Dirk Joberty, Gerard Lind, Kenneth E. Locke, Kelly Maller, Claire Martinod, Kimberly Patten, Chris Polyakova, Oxana Rise, Cecil E. Rüdiger, Martin Sheppard, Robert J. Slade, Daniel J. Thomas, Pamela Thorpe, Jim Yao, Gang Drewes, Gerard Wagner, Denisa D. Thompson, Paul R. Prinjha, Rab K. Wilson, David M. |
| author_sort | Lewis, Huw D. |
| collection | PubMed |
| description | PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases, through clinical genetics and gene disruption in mice. Novel, selective PAD4 inhibitors binding to a calcium-deficient form of the PAD4 enzyme have, for the first time, validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation. The therapeutic potential of PAD4 inhibitors can now be explored. |
| format | Online Article Text |
| id | pubmed-4397581 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-43975812015-09-01 Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation Lewis, Huw D. Liddle, John Coote, Jim E. Atkinson, Stephen J. Barker, Michael D. Bax, Benjamin, D. Bicker, Kevin L. Bingham, Ryan P. Campbell, Matthew Chen, Yu Hua Chung, Chun-wa Craggs, Peter D. Davis, Rob P. Eberhard, Dirk Joberty, Gerard Lind, Kenneth E. Locke, Kelly Maller, Claire Martinod, Kimberly Patten, Chris Polyakova, Oxana Rise, Cecil E. Rüdiger, Martin Sheppard, Robert J. Slade, Daniel J. Thomas, Pamela Thorpe, Jim Yao, Gang Drewes, Gerard Wagner, Denisa D. Thompson, Paul R. Prinjha, Rab K. Wilson, David M. Nat Chem Biol Article PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases, through clinical genetics and gene disruption in mice. Novel, selective PAD4 inhibitors binding to a calcium-deficient form of the PAD4 enzyme have, for the first time, validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation. The therapeutic potential of PAD4 inhibitors can now be explored. 2015-01-26 2015-03 /pmc/articles/PMC4397581/ /pubmed/25622091 http://dx.doi.org/10.1038/nchembio.1735 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Lewis, Huw D. Liddle, John Coote, Jim E. Atkinson, Stephen J. Barker, Michael D. Bax, Benjamin, D. Bicker, Kevin L. Bingham, Ryan P. Campbell, Matthew Chen, Yu Hua Chung, Chun-wa Craggs, Peter D. Davis, Rob P. Eberhard, Dirk Joberty, Gerard Lind, Kenneth E. Locke, Kelly Maller, Claire Martinod, Kimberly Patten, Chris Polyakova, Oxana Rise, Cecil E. Rüdiger, Martin Sheppard, Robert J. Slade, Daniel J. Thomas, Pamela Thorpe, Jim Yao, Gang Drewes, Gerard Wagner, Denisa D. Thompson, Paul R. Prinjha, Rab K. Wilson, David M. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation |
| title | Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation |
| title_full | Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation |
| title_fullStr | Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation |
| title_full_unstemmed | Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation |
| title_short | Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation |
| title_sort | inhibition of pad4 activity is sufficient to disrupt mouse and human net formation |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397581/ https://www.ncbi.nlm.nih.gov/pubmed/25622091 http://dx.doi.org/10.1038/nchembio.1735 |
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