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Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders
OBJECTIVES: Spermidine/spermine-N(1)-acetytransferase (SSAT) is the key enzyme in the catabolism of polyamines that are involved in regulating NMDA functioning. Over expression of SSAT leads to abnormal metabolic cycling and may disrupt NMDA receptor signaling. In fact, the HIV protein Tat induces n...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397651/ https://www.ncbi.nlm.nih.gov/pubmed/25893137 http://dx.doi.org/10.4172/2155-6113.1000312 |