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Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders

OBJECTIVES: Spermidine/spermine-N(1)-acetytransferase (SSAT) is the key enzyme in the catabolism of polyamines that are involved in regulating NMDA functioning. Over expression of SSAT leads to abnormal metabolic cycling and may disrupt NMDA receptor signaling. In fact, the HIV protein Tat induces n...

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Detalles Bibliográficos
Autores principales:	Merali, Salim, Barrero, Carlos A., Sacktor, Ned C., Haughey, Norman J., Datta, Prasun K., Langford, Dianne, Khalili, Kamel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397651/ https://www.ncbi.nlm.nih.gov/pubmed/25893137 http://dx.doi.org/10.4172/2155-6113.1000312

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