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Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya

Foot and mouth disease (FMD) is a highly transmissible viral infection of cloven hooved animals associated with severe economic losses when introduced into FMD-free countries. Information on the impact of the disease in FMDV-endemic countries is poorly characterised yet essential for the prioritisat...

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Autores principales: Lyons, Nicholas A, Alexander, Neal, Stӓrk, Katharina DC, Dulu, Thomas D, Rushton, Jonathan, Fine, Paul EM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397692/
https://www.ncbi.nlm.nih.gov/pubmed/25889460
http://dx.doi.org/10.1186/s13567-015-0173-4
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author Lyons, Nicholas A
Alexander, Neal
Stӓrk, Katharina DC
Dulu, Thomas D
Rushton, Jonathan
Fine, Paul EM
author_facet Lyons, Nicholas A
Alexander, Neal
Stӓrk, Katharina DC
Dulu, Thomas D
Rushton, Jonathan
Fine, Paul EM
author_sort Lyons, Nicholas A
collection PubMed
description Foot and mouth disease (FMD) is a highly transmissible viral infection of cloven hooved animals associated with severe economic losses when introduced into FMD-free countries. Information on the impact of the disease in FMDV-endemic countries is poorly characterised yet essential for the prioritisation of scarce resources for disease control programmes. A FMD (virus serotype SAT2) outbreak on a large-scale dairy farm in Nakuru County, Kenya provided an opportunity to evaluate the impact of FMD on clinical mastitis and culling rate. A cohort approach followed animals over a 12-month period after the commencement of the outbreak. For culling, all animals were included; for mastitis, those over 18 months of age. FMD was recorded in 400/644 cattle over a 29-day period. During the follow-up period 76 animals were culled or died whilst in the over 18 month old cohort 63 developed clinical mastitis. Hazard ratios (HR) were generated using Cox regression accounting for non-proportional hazards by inclusion of time-varying effects. Univariable analysis showed FMD cases were culled sooner but there was no effect on clinical mastitis. After adjusting for possible confounders and inclusion of time-varying effects there was weak evidence to support an effect of FMD on culling (HR = 1.7, 95% confidence intervals [CI] 0.88-3.1, P = 0.12). For mastitis, there was stronger evidence of an increased rate in the first month after the onset of the outbreak (HR = 2.9, 95%CI 0.97-8.9, P = 0.057). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13567-015-0173-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-43976922015-04-16 Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya Lyons, Nicholas A Alexander, Neal Stӓrk, Katharina DC Dulu, Thomas D Rushton, Jonathan Fine, Paul EM Vet Res Research Article Foot and mouth disease (FMD) is a highly transmissible viral infection of cloven hooved animals associated with severe economic losses when introduced into FMD-free countries. Information on the impact of the disease in FMDV-endemic countries is poorly characterised yet essential for the prioritisation of scarce resources for disease control programmes. A FMD (virus serotype SAT2) outbreak on a large-scale dairy farm in Nakuru County, Kenya provided an opportunity to evaluate the impact of FMD on clinical mastitis and culling rate. A cohort approach followed animals over a 12-month period after the commencement of the outbreak. For culling, all animals were included; for mastitis, those over 18 months of age. FMD was recorded in 400/644 cattle over a 29-day period. During the follow-up period 76 animals were culled or died whilst in the over 18 month old cohort 63 developed clinical mastitis. Hazard ratios (HR) were generated using Cox regression accounting for non-proportional hazards by inclusion of time-varying effects. Univariable analysis showed FMD cases were culled sooner but there was no effect on clinical mastitis. After adjusting for possible confounders and inclusion of time-varying effects there was weak evidence to support an effect of FMD on culling (HR = 1.7, 95% confidence intervals [CI] 0.88-3.1, P = 0.12). For mastitis, there was stronger evidence of an increased rate in the first month after the onset of the outbreak (HR = 2.9, 95%CI 0.97-8.9, P = 0.057). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13567-015-0173-4) contains supplementary material, which is available to authorized users. BioMed Central 2015-04-16 2015 /pmc/articles/PMC4397692/ /pubmed/25889460 http://dx.doi.org/10.1186/s13567-015-0173-4 Text en © Lyons et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Lyons, Nicholas A
Alexander, Neal
Stӓrk, Katharina DC
Dulu, Thomas D
Rushton, Jonathan
Fine, Paul EM
Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya
title Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya
title_full Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya
title_fullStr Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya
title_full_unstemmed Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya
title_short Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya
title_sort impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in kenya
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397692/
https://www.ncbi.nlm.nih.gov/pubmed/25889460
http://dx.doi.org/10.1186/s13567-015-0173-4
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