Cargando…
A combination Alzheimer’s therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice
BACKGROUND: Accumulating evidence indicates that partial inhibition of β-site APP-cleaving enzyme 1 (BACE1), which initiates amyloid-β (Aβ) production, mitigates Alzheimer’s disease (AD)-like pathologies and memory deficits in a battery of transgenic mouse models. However, our previous investigation...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397831/ https://www.ncbi.nlm.nih.gov/pubmed/25884928 http://dx.doi.org/10.1186/s13041-015-0110-5 |