The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD

Using transgenic animals harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog. Unlike most genes mutated in ALS, which are ubiquitously expressed, the C9ORF72-ortholog was most highly transcribed in the neuronal populations sensitive to degeneration in...

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Autores principales: Suzuki, Naoki, Maroof, Asif, Merkle, Florian T, Koszka, Kathryn, Intoh, Atsushi, Armstrong, Ian, Moccia, Rob, Davis-Dusenbery, Brandi N, Eggan, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397902/
https://www.ncbi.nlm.nih.gov/pubmed/24185425
http://dx.doi.org/10.1038/nn.3566
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author Suzuki, Naoki
Maroof, Asif
Merkle, Florian T
Koszka, Kathryn
Intoh, Atsushi
Armstrong, Ian
Moccia, Rob
Davis-Dusenbery, Brandi N
Eggan, Kevin
author_facet Suzuki, Naoki
Maroof, Asif
Merkle, Florian T
Koszka, Kathryn
Intoh, Atsushi
Armstrong, Ian
Moccia, Rob
Davis-Dusenbery, Brandi N
Eggan, Kevin
author_sort Suzuki, Naoki
collection PubMed
description Using transgenic animals harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog. Unlike most genes mutated in ALS, which are ubiquitously expressed, the C9ORF72-ortholog was most highly transcribed in the neuronal populations sensitive to degeneration in ALS and FTD. Thus, our study provides a potential explanation for the cell type specificity of neuronal degeneration caused by C9ORF72 mutations.
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spelling pubmed-43979022015-04-15 The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD Suzuki, Naoki Maroof, Asif Merkle, Florian T Koszka, Kathryn Intoh, Atsushi Armstrong, Ian Moccia, Rob Davis-Dusenbery, Brandi N Eggan, Kevin Nat Neurosci Article Using transgenic animals harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog. Unlike most genes mutated in ALS, which are ubiquitously expressed, the C9ORF72-ortholog was most highly transcribed in the neuronal populations sensitive to degeneration in ALS and FTD. Thus, our study provides a potential explanation for the cell type specificity of neuronal degeneration caused by C9ORF72 mutations. 2013-11-03 2013-12 /pmc/articles/PMC4397902/ /pubmed/24185425 http://dx.doi.org/10.1038/nn.3566 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Suzuki, Naoki
Maroof, Asif
Merkle, Florian T
Koszka, Kathryn
Intoh, Atsushi
Armstrong, Ian
Moccia, Rob
Davis-Dusenbery, Brandi N
Eggan, Kevin
The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD
title The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD
title_full The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD
title_fullStr The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD
title_full_unstemmed The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD
title_short The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD
title_sort mouse c9orf72 ortholog is enriched in neurons known to degenerate in als and ftd
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397902/
https://www.ncbi.nlm.nih.gov/pubmed/24185425
http://dx.doi.org/10.1038/nn.3566
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