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The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD

Using transgenic animals harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog. Unlike most genes mutated in ALS, which are ubiquitously expressed, the C9ORF72-ortholog was most highly transcribed in the neuronal populations sensitive to degeneration in...

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Detalles Bibliográficos
Autores principales:	Suzuki, Naoki, Maroof, Asif, Merkle, Florian T, Koszka, Kathryn, Intoh, Atsushi, Armstrong, Ian, Moccia, Rob, Davis-Dusenbery, Brandi N, Eggan, Kevin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397902/ https://www.ncbi.nlm.nih.gov/pubmed/24185425 http://dx.doi.org/10.1038/nn.3566

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