Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients

In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ...

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Detalles Bibliográficos
Autores principales: Naganawa, Kosuke, Takayama, Eiji, Adachi, Makoto, Mitsudo, Kenji, Iida, Masaki, Kamiya-Mizuno, Masako, Kawaki, Harumi, Ichinose, Masao, Motohashi, Masayuki, Muramatsu, Yasunori, Tohnai, Iwai, Sumitomo, Shin-Ichiro, Shikimori, Michio, Kondoh, Nobuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397950/
https://www.ncbi.nlm.nih.gov/pubmed/25893021
http://dx.doi.org/10.2174/1874210601509010120
Descripción
Sumario:In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.

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