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Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α(+)thalassemia

BACKGROUND: Individually, the red blood cell (RBC) polymorphisms sickle cell trait (HbAS) and α(+)thalassemia protect against severe Plasmodium falciparum malaria. It has been shown through epidemiological studies that the co-inheritance of both conditions results in a loss of the protection afforde...

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Detalles Bibliográficos
Autores principales:	Herbert Opi, D., Ochola, Lucy B., Tendwa, Metrine, Siddondo, Bethsheba R., Ocholla, Harold, Fanjo, Harry, Ghumra, Ashfaq, Ferguson, David J.P., Alexandra Rowe, J., Williams, Thomas N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397954/ https://www.ncbi.nlm.nih.gov/pubmed/25893206 http://dx.doi.org/10.1016/j.ebiom.2014.10.006

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